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10.7861/clinmed.2020.1007 http://scihub22266oqcxt.onion/10.7861/clinmed.2020.1007 33727368!8140713!33727368     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Clin+Med+(Lond) 2021 ; 21 (3): e300-e305 Nephropedia Template TP {{tp|p=33727368|t=2021. Real-world experience of SARS-CoV-2 antibody assays in UK healthcare workers |pdf=|usr=}}{{33727368}} gab.com Text Real-world experience of SARS-CoV-2 antibody assays in UK healthcare workers JO: Clin Med (Lond) http://www.kidney.de/pget.php?&tw=1&pmid=33727368 #FOAvip BACKGROUND: The seroprevalence of antibodies to SARS-CoV-2 in healthcare workers is variable throughout the world. This study compares the use of two antibody assays among large cohorts of healthcare workers in southern England. METHODS: This cohort study includes data obtained from staff at Western Sussex Hospitals NHS Foundation Trust (WSHT) and Brighton and Sussex University Hospitals (BSUH) during voluntary antibody testing, using Abbott and Roche SARS-CoV-2 antibody assays at each Trust respectively. RESULTS: The observed seroprevalence level was 7.9% for the WSHT/Abbott cohort versus 13% for the BSUH/Roche cohort. Based on a previous positive PCR, we find that the false-negative rate of the Abbott and Roche assays were 60.2% and 19% respectively, implying sensitivity levels of 39.8% and 81%. Within these cohorts, seropositivity was most strongly associated with those of South Asian ethnicity, allied health professionals and male sex (p<0.0001). CONCLUSIONS: In this real-world study, neither antibody test performed to the specification level stated by the manufacturer. More rigorous testing of these and other assays in target populations is recommended prior to widespread usage if they are to provide data that might be useful to control the pandemic. Twit Text FOAVip Real-world experience of SARS-CoV-2 antibody assays in UK healthcare workers ????Clin Med (Lond) http://www.kidney.de/pget.php?&tw=1&pmid=33727368 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33727368 #FOAvip English Wikipedia <ref>{{Cite pmid|33727368}}</ref> Real-world experience of SARS-CoV-2 antibody assays in UK healthcare workers #MMPMID33727368 Robinson AV; Weaving G; Philips BJ; Eziefula AC; Shipman KE; Chevassut T Clin Med (Lond) 2021[May]; 21 (3): e300-e305 PMID33727368show ga BACKGROUND: The seroprevalence of antibodies to SARS-CoV-2 in healthcare workers is variable throughout the world. This study compares the use of two antibody assays among large cohorts of healthcare workers in southern England. METHODS: This cohort study includes data obtained from staff at Western Sussex Hospitals NHS Foundation Trust (WSHT) and Brighton and Sussex University Hospitals (BSUH) during voluntary antibody testing, using Abbott and Roche SARS-CoV-2 antibody assays at each Trust respectively. RESULTS: The observed seroprevalence level was 7.9% for the WSHT/Abbott cohort versus 13% for the BSUH/Roche cohort. Based on a previous positive PCR, we find that the false-negative rate of the Abbott and Roche assays were 60.2% and 19% respectively, implying sensitivity levels of 39.8% and 81%. Within these cohorts, seropositivity was most strongly associated with those of South Asian ethnicity, allied health professionals and male sex (p<0.0001). CONCLUSIONS: In this real-world study, neither antibody test performed to the specification level stated by the manufacturer. More rigorous testing of these and other assays in target populations is recommended prior to widespread usage if they are to provide data that might be useful to control the pandemic. |*COVID-19[MESH] |*SARS-CoV-2[MESH] |Antibodies, Viral[MESH] |Cohort Studies[MESH] |England[MESH] |Health Personnel[MESH] |Humans[MESH] |Male[MESH] |Seroepidemiologic Studies[MESH]Real-world experience of SARS-CoV-2 antibody assays in UK healthcare w(epmc).pdf DeepDyve Pubget Overpricing