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10.1016/j.jiac.2021.02.029 http://scihub22266oqcxt.onion/10.1016/j.jiac.2021.02.029 33727026!7931724!33727026     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33727026&cmd=llinks): Failed to open stream: HTTP request failed! 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The evaluation of a newly developed antigen test (QuickNavi-COVID19 Ag) for SARS-CoV-2: A prospective observational study in Japan |pdf=|usr=}}{{33727026}} gab.com Text The evaluation of a newly developed antigen test (QuickNavi-COVID19 Ag) for SARS-CoV-2: A prospective observational study in Japan JO: J Infect Chemother http://www.kidney.de/pget.php?&tw=1&pmid=33727026 #FOAvip INTRODUCTION: Several antigen tests for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been developed worldwide, but their clinical utility has not been well established. In this study, we evaluated the analytical and clinical performance of QuickNavi-COVID19 Ag, a newly developed antigen test in Japan. METHODS: This prospective observational study was conducted at a PCR center between October 7 and December 5, 2020. The included patients were referred from a local public health center and 89 primary care facilities. We simultaneously obtained two nasopharyngeal samples with flocked swabs; one was used for the antigen test and the other for real-time reverse transcription PCR (RT-PCR). Using the results of real-time RT-PCR as a reference, the performance of the antigen test was evaluated. RESULTS: A total of 1186 patients were included in this study, and the real-time RT-PCR detected SARS-CoV-2 in 105 (8.9%). Of these 105 patients, 33 (31.4%) were asymptomatic. The antigen test provided a 98.8% (95% confidence interval [CI]: 98.0%-99.4%) concordance rate with real-time RT-PCR, along with a sensitivity of 86.7% (95% CI: 78.6%-92.5%) and a specificity of 100% (95% CI: 99.7%-100%). False-negatives were observed in 14 patients, 8 of whom were asymptomatic and had a low viral load (cycle threshold (Ct) > 30). In symptomatic patients, the sensitivity was 91.7% (95% CI: 82.7%-96.9%). CONCLUSION: QuickNavi-COVID19 Ag showed high specificity and sufficient sensitivity for the detection of SARS-CoV-2. This test is a promising potential diagnostic modality especially in symptomatic patients. Twit Text FOAVip The evaluation of a newly developed antigen test (QuickNavi-COVID19 Ag) for SARS-CoV-2: A prospective observational study in Japan ????J Infect Chemother http://www.kidney.de/pget.php?&tw=1&pmid=33727026 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33727026 #FOAvip English Wikipedia <ref>{{Cite pmid|33727026}}</ref> The evaluation of a newly developed antigen test (QuickNavi-COVID19 Ag) for SARS-CoV-2: A prospective observational study in Japan #MMPMID33727026 Takeuchi Y; Akashi Y; Kato D; Kuwahara M; Muramatsu S; Ueda A; Notake S; Nakamura K; Ishikawa H; Suzuki H J Infect Chemother 2021[Jun]; 27 (6): 890-894 PMID33727026show ga INTRODUCTION: Several antigen tests for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been developed worldwide, but their clinical utility has not been well established. In this study, we evaluated the analytical and clinical performance of QuickNavi-COVID19 Ag, a newly developed antigen test in Japan. METHODS: This prospective observational study was conducted at a PCR center between October 7 and December 5, 2020. The included patients were referred from a local public health center and 89 primary care facilities. We simultaneously obtained two nasopharyngeal samples with flocked swabs; one was used for the antigen test and the other for real-time reverse transcription PCR (RT-PCR). Using the results of real-time RT-PCR as a reference, the performance of the antigen test was evaluated. RESULTS: A total of 1186 patients were included in this study, and the real-time RT-PCR detected SARS-CoV-2 in 105 (8.9%). Of these 105 patients, 33 (31.4%) were asymptomatic. The antigen test provided a 98.8% (95% confidence interval [CI]: 98.0%-99.4%) concordance rate with real-time RT-PCR, along with a sensitivity of 86.7% (95% CI: 78.6%-92.5%) and a specificity of 100% (95% CI: 99.7%-100%). False-negatives were observed in 14 patients, 8 of whom were asymptomatic and had a low viral load (cycle threshold (Ct) > 30). In symptomatic patients, the sensitivity was 91.7% (95% CI: 82.7%-96.9%). CONCLUSION: QuickNavi-COVID19 Ag showed high specificity and sufficient sensitivity for the detection of SARS-CoV-2. This test is a promising potential diagnostic modality especially in symptomatic patients. |Adolescent[MESH] |Adult[MESH] |Aged[MESH] |Antigens, Viral/*isolation & purification[MESH] |COVID-19 Testing/*methods[MESH] |COVID-19/*diagnosis[MESH] |Female[MESH] |Humans[MESH] |Japan[MESH] |Male[MESH] |Middle Aged[MESH] |SARS-CoV-2[MESH] |Sensitivity and Specificity[MESH]The evaluation of a newly developed antigen test (QuickNavi-COVID19 Ag(epmc).pdf DeepDyve Pubget Overpricing