Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText.
Kick-your-searchterm to multiple Engines kick-your-query now !>
A dictionary by aggregated review articles of nephrology, medicine and the life sciences
Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

suck abstract from ncbi


10.1186/s40249-021-00812-9

http://scihub22266oqcxt.onion/10.1186/s40249-021-00812-9
suck pdf from google scholar
33726861!7962087!33726861
unlimited free pdf from europmc33726861    free
PDF from PMC    free
html from PMC    free

suck abstract from ncbi

pmid33726861      Infect+Dis+Poverty 2021 ; 10 (1): 28
Nephropedia Template TP

gab.com Text

Twit Text FOAVip

Twit Text #

English Wikipedia


  • Human coronaviruses and therapeutic drug discovery #MMPMID33726861
  • Song LG; Xie QX; Lao HL; Lv ZY
  • Infect Dis Poverty 2021[Mar]; 10 (1): 28 PMID33726861show ga
  • BACKGROUND: Coronaviruses (CoVs) are distributed worldwide and have various susceptible hosts; CoVs infecting humans are called human coronaviruses (HCoVs). Although HCoV-specific drugs are still lacking, many potent targets for drug discovery are being explored, and many vigorously designed clinical trials are being carried out in an orderly manner. The aim of this review was to gain a comprehensive understanding of the current status of drug development against HCoVs, particularly severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). MAIN TEXT: A scoping review was conducted by electronically searching research studies, reviews, and clinical trials in PubMed and the CNKI. Studies on HCoVs and therapeutic drug discovery published between January 2000 and October 2020 and in English or Chinese were included, and the information was summarized. Of the 3248 studies identified, 159 publication were finally included. Advances in drug development against HCoV, especially SARS-CoV-2, are summarized under three categories: antiviral drugs aimed at inhibiting the HCoV proliferation process, drugs acting on the host's immune system, and drugs derived from plants with potent activity. Furthermore, clinical trials of drugs targeting SARS-CoV-2 are summarized. CONCLUSIONS: During the spread of COVID-19 outbreak, great efforts have been made in therapeutic drug discovery against the virus, although the pharmacological effects and adverse reactions of some drugs under study are still unclear. However, well-designed high-quality studies are needed to further study the effectiveness and safety of these potential drugs so as to provide valid recommendations for better control of the COVID-19 pandemic.
  • |*Drug Discovery/methods[MESH]
  • |Antiviral Agents/*pharmacology/therapeutic use[MESH]
  • |Biomarkers[MESH]
  • |COVID-19 Drug Treatment[MESH]
  • |COVID-19/metabolism/virology[MESH]
  • |Coronavirus Infections/drug therapy/metabolism/*virology[MESH]
  • |Coronavirus/classification/*drug effects/*physiology[MESH]
  • |Drug Development[MESH]
  • |Gene Expression Regulation, Viral[MESH]
  • |Host-Pathogen Interactions[MESH]
  • |Humans[MESH]
  • |Medicine, Traditional[MESH]
  • |Molecular Targeted Therapy[MESH]
  • |SARS-CoV-2/drug effects[MESH]


  • DeepDyve
  • Pubget Overpricing
  • suck abstract from ncbi

    Linkout box