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10.1093/infdis/jiab142

http://scihub22266oqcxt.onion/10.1093/infdis/jiab142
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suck abstract from ncbi


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pmid33725725      J+Infect+Dis 2022 ; 226 (8): 1357-1361
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  • Rapidly Increasing Severe Acute Respiratory Syndrome Coronavirus 2 Neutralization by Intravenous Immunoglobulins Produced From Plasma Collected During the 2020 Pandemic #MMPMID33725725
  • Farcet MR; Karbiener M; Schwaiger J; Ilk R; Kreil TR
  • J Infect Dis 2022[Oct]; 226 (8): 1357-1361 PMID33725725show ga
  • Immunoglobulin lots (N = 176) released since March 2020 were tested for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) neutralizing antibodies, with first positive results for September 2020 lots (mean, 1.7 IU/mL; 46% of lots positive). From there, values steadily increased, in correlation with the cumulative coronavirus disease 2019 (COVID-19) incidence, to reach a mean of 31.2 IU/mL and 93% of lots positive by January 2021. Extrapolating the correlation, immunoglobulins could reach an anti-SARS-CoV-2 potency of approximately 345 IU/mL by July 2021. At that stage, prophylactic immunoglobulin treatment for primary/secondary immunodeficiency could contain similar doses of anti-SARS-CoV-2 as convalescent plasma that is used for treatment of COVID-19.
  • |*COVID-19/therapy[MESH]
  • |*SARS-CoV-2[MESH]
  • |Antibodies, Neutralizing[MESH]
  • |Antibodies, Viral[MESH]
  • |COVID-19 Serotherapy[MESH]
  • |Humans[MESH]
  • |Immunization, Passive/methods[MESH]
  • |Immunoglobulins, Intravenous/therapeutic use[MESH]


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