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10.1371/journal.pone.0248730 http://scihub22266oqcxt.onion/10.1371/journal.pone.0248730 33725024!7963026!33725024     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       PLoS+One 2021 ; 16 (3): e0248730 Nephropedia Template TP {{tp|p=33725024|t=2021. Variability in digestive and respiratory tract Ace2 expression is associated with the microbiome |pdf=|usr=}}{{33725024}} gab.com Text Variability in digestive and respiratory tract Ace2 expression is associated with the microbiome JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=33725024 #FOAvip COVID-19 (coronavirus disease 2019) patients exhibiting gastrointestinal symptoms are reported to have worse prognosis. Ace2 (angiotensin-converting enzyme 2), the gene encoding the host protein to which SARS-CoV-2 spike proteins bind, is expressed in the gut and therefore may be a target for preventing or reducing severity of COVID-19. Here we test the hypothesis that Ace2 expression in the gastrointestinal and respiratory tracts is modulated by the microbiome. We used quantitative PCR to profile Ace2 expression in germ-free mice, conventional raised specific pathogen-free mice, and gnotobiotic mice colonized with different microbiota. Intestinal Ace2 expression levels were significantly higher in germ-free mice compared to conventional mice. A similar trend was observed in the respiratory tract. Intriguingly, microbiota depletion via antibiotics partially recapitulated the germ-free phenotype, suggesting potential for microbiome-mediated regulation of Ace2 expression. Variability in intestinal Ace2 expression was observed in gnotobiotic mice colonized with different microbiota, partially attributable to differences in microbiome-encoded proteases and peptidases. Together, these data suggest that the microbiome may be one modifiable factor determining COVID-19 infection risk and disease severity. Twit Text FOAVip Variability in digestive and respiratory tract Ace2 expression is associated with the microbiome ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=33725024 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33725024 #FOAvip English Wikipedia <ref>{{Cite pmid|33725024}}</ref> Variability in digestive and respiratory tract Ace2 expression is associated with the microbiome #MMPMID33725024 Koester ST; Li N; Lachance DM; Morella NM; Dey N PLoS One 2021[]; 16 (3): e0248730 PMID33725024show ga COVID-19 (coronavirus disease 2019) patients exhibiting gastrointestinal symptoms are reported to have worse prognosis. Ace2 (angiotensin-converting enzyme 2), the gene encoding the host protein to which SARS-CoV-2 spike proteins bind, is expressed in the gut and therefore may be a target for preventing or reducing severity of COVID-19. Here we test the hypothesis that Ace2 expression in the gastrointestinal and respiratory tracts is modulated by the microbiome. We used quantitative PCR to profile Ace2 expression in germ-free mice, conventional raised specific pathogen-free mice, and gnotobiotic mice colonized with different microbiota. Intestinal Ace2 expression levels were significantly higher in germ-free mice compared to conventional mice. A similar trend was observed in the respiratory tract. Intriguingly, microbiota depletion via antibiotics partially recapitulated the germ-free phenotype, suggesting potential for microbiome-mediated regulation of Ace2 expression. Variability in intestinal Ace2 expression was observed in gnotobiotic mice colonized with different microbiota, partially attributable to differences in microbiome-encoded proteases and peptidases. Together, these data suggest that the microbiome may be one modifiable factor determining COVID-19 infection risk and disease severity. |*Gastrointestinal Microbiome[MESH] |Adenomatous Polyposis Coli Protein/deficiency/genetics[MESH] |Angiotensin-Converting Enzyme 2/genetics/*metabolism[MESH] |Animals[MESH] |Colon/*enzymology[MESH] |Female[MESH] |Gene Expression[MESH] |Interleukin-10/deficiency/genetics[MESH] |Intestine, Small/*enzymology[MESH] |Lung/*enzymology[MESH] |Male[MESH] |Mice[MESH] |Mice, Inbred C57BL[MESH]Variability in digestive and respiratory tract Ace2 expression is asso(epmc).pdf DeepDyve Pubget Overpricing