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10.1002/rmv.2231 http://scihub22266oqcxt.onion/10.1002/rmv.2231 33724631!8250244!33724631     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Rev+Med+Virol 2021 ; 31 (6): e2231 Nephropedia Template TP {{tp|p=33724631|t=2021. Neutralising antibody escape of SARS-CoV-2 spike protein: Risk assessment for antibody-based Covid-19 therapeutics and vaccines |pdf=|usr=}}{{33724631}} gab.com Text Neutralising antibody escape of SARS-CoV-2 spike protein: Risk assessment for antibody-based Covid-19 therapeutics and vaccines JO: Rev Med Virol http://www.kidney.de/pget.php?&tw=1&pmid=33724631 #FOAvip The Spike protein is the target of both antibody-based therapeutics (convalescent plasma, polyclonal serum, monoclonal antibodies) and vaccines. Mutations in Spike could affect efficacy of those treatments. Hence, monitoring of mutations is necessary to forecast and readapt the inventory of therapeutics. Different phylogenetic nomenclatures have been used for the currently circulating SARS-CoV-2 clades. The Spike protein has different hotspots of mutation and deletion, the most dangerous for immune escape being the ones within the receptor binding domain (RBD), such as K417N/T, N439K, L452R, Y453F, S477N, E484K, and N501Y. Convergent evolution has led to different combinations of mutations among different clades. In this review we focus on the main variants of concern, that is, the so-called UK (B.1.1.7), South African (B.1.351) and Brazilian (P.1) strains. Twit Text FOAVip Neutralising antibody escape of SARS-CoV-2 spike protein: Risk assessment for antibody-based Covid-19 therapeutics and vaccines ????Rev Med Virol http://www.kidney.de/pget.php?&tw=1&pmid=33724631 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33724631 #FOAvip English Wikipedia <ref>{{Cite pmid|33724631}}</ref> Neutralising antibody escape of SARS-CoV-2 spike protein: Risk assessment for antibody-based Covid-19 therapeutics and vaccines #MMPMID33724631 Focosi D; Maggi F Rev Med Virol 2021[Nov]; 31 (6): e2231 PMID33724631show ga The Spike protein is the target of both antibody-based therapeutics (convalescent plasma, polyclonal serum, monoclonal antibodies) and vaccines. Mutations in Spike could affect efficacy of those treatments. Hence, monitoring of mutations is necessary to forecast and readapt the inventory of therapeutics. Different phylogenetic nomenclatures have been used for the currently circulating SARS-CoV-2 clades. The Spike protein has different hotspots of mutation and deletion, the most dangerous for immune escape being the ones within the receptor binding domain (RBD), such as K417N/T, N439K, L452R, Y453F, S477N, E484K, and N501Y. Convergent evolution has led to different combinations of mutations among different clades. In this review we focus on the main variants of concern, that is, the so-called UK (B.1.1.7), South African (B.1.351) and Brazilian (P.1) strains. |Antibodies, Monoclonal/chemistry/metabolism/*therapeutic use[MESH] |Antibodies, Neutralizing/chemistry/metabolism/*therapeutic use[MESH] |Antibodies, Viral/chemistry/metabolism/therapeutic use[MESH] |Brazil/epidemiology[MESH] |COVID-19 Serotherapy[MESH] |COVID-19 Vaccines/administration & dosage[MESH] |COVID-19/epidemiology/immunology/*therapy/virology[MESH] |Gene Expression[MESH] |Humans[MESH] |Immune Evasion[MESH] |Immunization, Passive/methods[MESH] |Mutation[MESH] |Phylogeny[MESH] |Protein Binding[MESH] |Risk Assessment[MESH] |SARS-CoV-2/classification/drug effects/*genetics/immunology[MESH] |South Africa/epidemiology[MESH] |Spike Glycoprotein, Coronavirus/*genetics/immunology[MESH]Neutralising antibody escape of SARS-CoV-2 spike protein: Risk assessm(epmc).pdf DeepDyve Pubget Overpricing