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10.1016/j.genrep.2021.101077

http://scihub22266oqcxt.onion/10.1016/j.genrep.2021.101077
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33723522!7946539!33723522
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suck abstract from ncbi

pmid33723522      Gene+Rep 2021 ; 23 (ä): 101077
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  • ACE2: At the crossroad of COVID-19 and lung cancer #MMPMID33723522
  • Gottschalk G; Knox K; Roy A
  • Gene Rep 2021[Jun]; 23 (ä): 101077 PMID33723522show ga
  • Upregulation of Angiotensin Converting Enzyme-2 (ACE2) was frequently observed in patients with lung cancer. Interestingly, our recent study revealed that the same ACE2 receptor was also strongly upregulated in lungs during SARS-CoV2 infection. Therefore, it is possible that the upregulated expression of ACE2 in lung tumors might increase the susceptibility to COVID-19 infection in lung cancer patients. However, the molecular mechanism for the regulation of ACE2 is known neither in lung tumors nor in COVID-19. Under this review, we attempt to identify transcription factors (TFs) in the promoter of ACE2 that promote the expression of ACE2 both in COVID-19 infection and lung cancer. This review would decipher the molecular role of ACE2 in the upscaled fatality of lung cancer patients suffering from COVID-19.
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