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10.1093/ofid/ofab048

http://scihub22266oqcxt.onion/10.1093/ofid/ofab048
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33723510!7928697!33723510
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suck abstract from ncbi


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pmid33723510      Open+Forum+Infect+Dis 2021 ; 8 (3): ofab048
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  • Infectious Period of Severe Acute Respiratory Syndrome Coronavirus 2 in 17 Nursing Home Residents-Arkansas, June-August 2020 #MMPMID33723510
  • Surie D; Huang JY; Brown AC; Gable P; Biedron C; Gilbert SE; Garner K; Bollinger S; Gulley T; Haney T; Lyons AK; Beshearse E; Gregory CJ; Sabour S; Clemmons NS; James AE; Tamin A; Reese N; Perry-Dow KA; Brown R; Harcourt JL; Campbell D; Houston H; Chakravorty R; Paulick A; Whitaker B; Murdoch J; Spicer L; Stumpf MM; Mills L; Coughlin MM; Higdem P; Rasheed MAU; Lonsway D; Bhatnagar A; Kothari A; Anderson K; Thornburg NJ; Breaker E; Adamczyk M; McAllister GA; Halpin AL; Seely KA; Patil N; McDonald LC; Kutty PK
  • Open Forum Infect Dis 2021[Mar]; 8 (3): ofab048 PMID33723510show ga
  • BACKGROUND: To estimate the infectious period of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in older adults with underlying conditions, we assessed duration of coronavirus disease 2019 (COVID-19) symptoms, reverse-transcription polymerase chain reaction (RT-PCR) positivity, and culture positivity among nursing home residents. METHODS: We enrolled residents within 15 days of their first positive SARS-CoV-2 test (diagnosis) at an Arkansas facility from July 7 to 15, 2020 and instead them for 42 days. Every 3 days for 21 days and then weekly, we assessed COVID-19 symptoms, collected specimens (oropharyngeal, anterior nares, and saliva), and reviewed medical charts. Blood for serology was collected on days 0, 6, 12, 21, and 42. Infectivity was defined by positive culture. Duration of culture positivity was compared with duration of COVID-19 symptoms and RT-PCR positivity. Data were summarized using measures of central tendency, frequencies, and proportions. RESULTS: We enrolled 17 of 39 (44%) eligible residents. Median participant age was 82 years (range, 58-97 years). All had >/=3 underlying conditions. Median duration of RT-PCR positivity was 22 days (interquartile range [IQR], 8-31 days) from diagnosis; median duration of symptoms was 42 days (IQR, 28-49 days). Of 9 (53%) participants with any culture-positive specimens, 1 (11%) severely immunocompromised participant remained culture-positive 19 days from diagnosis; 8 of 9 (89%) were culture-positive /=1 blood specimen; all participants were culture-negative before seroconversion. CONCLUSIONS: Duration of infectivity was considerably shorter than duration of symptoms and RT-PCR positivity. Severe immunocompromise may prolong SARS-CoV-2 infectivity. Seroconversion indicated noninfectivity in this cohort.
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