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10.1038/s41586-021-03426-1 http://scihub22266oqcxt.onion/10.1038/s41586-021-03426-1 33723411!9170116!33723411     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nature 2021 ; 593 (7858): 270-274 Nephropedia Template TP {{tp|p=33723411|t=2021. Increased mortality in community-tested cases of SARS-CoV-2 lineage B 1 1 7 |pdf=|usr=}}{{33723411}} gab.com Text Increased mortality in community-tested cases of SARS-CoV-2 lineage B 1 1 7 JO: Nature http://www.kidney.de/pget.php?&tw=1&pmid=33723411 #FOAvip SARS-CoV-2 lineage B.1.1.7, a variant that was first detected in the UK in September 2020(1), has spread to multiple countries worldwide. Several studies have established that B.1.1.7 is more transmissible than pre-existing variants, but have not identified whether it leads to any change in disease severity(2). Here we analyse a dataset that links 2,245,263 positive SARS-CoV-2 community tests and 17,452 deaths associated with COVID-19 in England from 1 November 2020 to 14 February 2021. For 1,146,534 (51%) of these tests, the presence or absence of B.1.1.7 can be identified because mutations in this lineage prevent PCR amplification of the spike (S) gene target (known as S gene target failure (SGTF)(1)). On the basis of 4,945 deaths with known SGTF status, we estimate that the hazard of death associated with SGTF is 55% (95% confidence interval, 39-72%) higher than in cases without SGTF after adjustment for age, sex, ethnicity, deprivation, residence in a care home, the local authority of residence and test date. This corresponds to the absolute risk of death for a 55-69-year-old man increasing from 0.6% to 0.9% (95% confidence interval, 0.8-1.0%) within 28 days of a positive test in the community. Correcting for misclassification of SGTF and missingness in SGTF status, we estimate that the hazard of death associated with B.1.1.7 is 61% (42-82%) higher than with pre-existing variants. Our analysis suggests that B.1.1.7 is not only more transmissible than pre-existing SARS-CoV-2 variants, but may also cause more severe illness. Twit Text FOAVip Increased mortality in community-tested cases of SARS-CoV-2 lineage B 1 1 7 ????Nature http://www.kidney.de/pget.php?&tw=1&pmid=33723411 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33723411 #FOAvip English Wikipedia <ref>{{Cite pmid|33723411}}</ref> Increased mortality in community-tested cases of SARS-CoV-2 lineage B 1 1 7 #MMPMID33723411 Davies NG; Jarvis CI; Edmunds WJ; Jewell NP; Diaz-Ordaz K; Keogh RH Nature 2021[May]; 593 (7858): 270-274 PMID33723411show ga SARS-CoV-2 lineage B.1.1.7, a variant that was first detected in the UK in September 2020(1), has spread to multiple countries worldwide. Several studies have established that B.1.1.7 is more transmissible than pre-existing variants, but have not identified whether it leads to any change in disease severity(2). Here we analyse a dataset that links 2,245,263 positive SARS-CoV-2 community tests and 17,452 deaths associated with COVID-19 in England from 1 November 2020 to 14 February 2021. For 1,146,534 (51%) of these tests, the presence or absence of B.1.1.7 can be identified because mutations in this lineage prevent PCR amplification of the spike (S) gene target (known as S gene target failure (SGTF)(1)). On the basis of 4,945 deaths with known SGTF status, we estimate that the hazard of death associated with SGTF is 55% (95% confidence interval, 39-72%) higher than in cases without SGTF after adjustment for age, sex, ethnicity, deprivation, residence in a care home, the local authority of residence and test date. This corresponds to the absolute risk of death for a 55-69-year-old man increasing from 0.6% to 0.9% (95% confidence interval, 0.8-1.0%) within 28 days of a positive test in the community. Correcting for misclassification of SGTF and missingness in SGTF status, we estimate that the hazard of death associated with B.1.1.7 is 61% (42-82%) higher than with pre-existing variants. Our analysis suggests that B.1.1.7 is not only more transmissible than pre-existing SARS-CoV-2 variants, but may also cause more severe illness. |*Phylogeny[MESH] |Adolescent[MESH] |Adult[MESH] |Aged[MESH] |Aged, 80 and over[MESH] |COVID-19/*mortality/*virology[MESH] |Child[MESH] |Child, Preschool[MESH] |England/epidemiology[MESH] |Ethnicity[MESH] |Evolution, Molecular[MESH] |Female[MESH] |Homes for the Aged[MESH] |Humans[MESH] |Infant[MESH] |Male[MESH] |Middle Aged[MESH] |Proportional Hazards Models[MESH] |Risk Assessment[MESH] |SARS-CoV-2/*classification/genetics/isolation & purification/*pathogenicity[MESH] |Survival Analysis[MESH] |Time Factors[MESH]Increased mortality in community-tested cases of SARS-CoV-2 lineage B (epmc).pdf DeepDyve Pubget Overpricing