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10.1038/s41598-021-85202-9 http://scihub22266oqcxt.onion/10.1038/s41598-021-85202-9 33723294!7960719!33723294     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2021 ; 11 (1): 5934 Nephropedia Template TP {{tp|p=33723294|t=2021. SARS-CoV-2-induced humoral immunity through B cell epitope analysis in COVID-19 infected individuals |pdf=|usr=}}{{33723294}} gab.com Text SARS-CoV-2-induced humoral immunity through B cell epitope analysis in COVID-19 infected individuals JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=33723294 #FOAvip The aim of this study is to understand adaptive immunity to SARS-CoV-2 through the analysis of B cell epitope and neutralizing activity in coronavirus disease 2019 (COVID-19) patients. We obtained serum from forty-three COVID-19 patients from patients in the intensive care unit of Osaka University Hospital (n = 12) and in Osaka City Juso Hospital (n = 31). Most individuals revealed neutralizing activity against SARS-CoV-2 assessed by a pseudotype virus-neutralizing assay. The antibody production against the spike glycoprotein (S protein) or receptor-binding domain (RBD) of SARS-CoV-2 was elevated, with large individual differences, as assessed by ELISA. We observed the correlation between neutralizing antibody titer and IgG, but not IgM, antibody titer of COVID-19 patients. In the analysis of the predicted the linear B cell epitopes, hot spots in the N-terminal domain of the S protein were observed in the serum from patients in the intensive care unit of Osaka University Hospital. Overall, the analysis of antibody production and B cell epitopes of the S protein from patient serum may provide a novel target for the vaccine development against SARS-CoV-2. Twit Text FOAVip SARS-CoV-2-induced humoral immunity through B cell epitope analysis in COVID-19 infected individuals ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=33723294 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33723294 #FOAvip English Wikipedia <ref>{{Cite pmid|33723294}}</ref> SARS-CoV-2-induced humoral immunity through B cell epitope analysis in COVID-19 infected individuals #MMPMID33723294 Yoshida S; Ono C; Hayashi H; Fukumoto S; Shiraishi S; Tomono K; Arase H; Matsuura Y; Nakagami H Sci Rep 2021[Mar]; 11 (1): 5934 PMID33723294show ga The aim of this study is to understand adaptive immunity to SARS-CoV-2 through the analysis of B cell epitope and neutralizing activity in coronavirus disease 2019 (COVID-19) patients. We obtained serum from forty-three COVID-19 patients from patients in the intensive care unit of Osaka University Hospital (n = 12) and in Osaka City Juso Hospital (n = 31). Most individuals revealed neutralizing activity against SARS-CoV-2 assessed by a pseudotype virus-neutralizing assay. The antibody production against the spike glycoprotein (S protein) or receptor-binding domain (RBD) of SARS-CoV-2 was elevated, with large individual differences, as assessed by ELISA. We observed the correlation between neutralizing antibody titer and IgG, but not IgM, antibody titer of COVID-19 patients. In the analysis of the predicted the linear B cell epitopes, hot spots in the N-terminal domain of the S protein were observed in the serum from patients in the intensive care unit of Osaka University Hospital. Overall, the analysis of antibody production and B cell epitopes of the S protein from patient serum may provide a novel target for the vaccine development against SARS-CoV-2. |*Immunity, Humoral[MESH] |Amino Acid Sequence[MESH] |Antibodies, Neutralizing/blood/immunology[MESH] |Antibodies, Viral/blood/immunology[MESH] |COVID-19/*epidemiology/*immunology/virology[MESH] |Enzyme-Linked Immunosorbent Assay[MESH] |Epitopes, B-Lymphocyte/*immunology[MESH] |Female[MESH] |Host-Pathogen Interactions[MESH] |Humans[MESH] |Male[MESH] |SARS-CoV-2/*immunology[MESH]SARS-CoV-2-induced humoral immunity through B cell epitope analysis in(epmc).pdf DeepDyve Pubget Overpricing