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10.1038/s41598-021-85049-0 http://scihub22266oqcxt.onion/10.1038/s41598-021-85049-0 33723270!7961020!33723270     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2021 ; 11 (1): 5890 Nephropedia Template TP {{tp|p=33723270|t=2021. The serotonin reuptake inhibitor Fluoxetine inhibits SARS-CoV-2 in human lung tissue |pdf=|usr=}}{{33723270}} gab.com Text The serotonin reuptake inhibitor Fluoxetine inhibits SARS-CoV-2 in human lung tissue JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=33723270 #FOAvip To circumvent time-consuming clinical trials, testing whether existing drugs are effective inhibitors of SARS-CoV-2, has led to the discovery of Remdesivir. We decided to follow this path and screened approved medications "off-label" against SARS-CoV-2. Fluoxetine inhibited SARS-CoV-2 at a concentration of 0.8 microg/ml significantly in these screenings, and the EC50 was determined with 387 ng/ml. Furthermore, Fluoxetine reduced viral infectivity in precision-cut human lung slices showing its activity in relevant human tissue targeted in severe infections. Fluoxetine treatment resulted in a decrease in viral protein expression. Fluoxetine is a racemate consisting of both stereoisomers, while the S-form is the dominant serotonin reuptake inhibitor. We found that both isomers show similar activity on the virus, indicating that the R-form might specifically be used for SARS-CoV-2 treatment. Fluoxetine inhibited neither Rabies virus, human respiratory syncytial virus replication nor the Human Herpesvirus 8 or Herpes simplex virus type 1 gene expression, indicating that it acts virus-specific. Moreover, since it is known that Fluoxetine inhibits cytokine release, we see the role of Fluoxetine in the treatment of SARS-CoV-2 infected patients of risk groups. Twit Text FOAVip The serotonin reuptake inhibitor Fluoxetine inhibits SARS-CoV-2 in human lung tissue ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=33723270 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33723270 #FOAvip English Wikipedia <ref>{{Cite pmid|33723270}}</ref> The serotonin reuptake inhibitor Fluoxetine inhibits SARS-CoV-2 in human lung tissue #MMPMID33723270 Zimniak M; Kirschner L; Hilpert H; Geiger N; Danov O; Oberwinkler H; Steinke M; Sewald K; Seibel J; Bodem J Sci Rep 2021[Mar]; 11 (1): 5890 PMID33723270show ga To circumvent time-consuming clinical trials, testing whether existing drugs are effective inhibitors of SARS-CoV-2, has led to the discovery of Remdesivir. We decided to follow this path and screened approved medications "off-label" against SARS-CoV-2. Fluoxetine inhibited SARS-CoV-2 at a concentration of 0.8 microg/ml significantly in these screenings, and the EC50 was determined with 387 ng/ml. Furthermore, Fluoxetine reduced viral infectivity in precision-cut human lung slices showing its activity in relevant human tissue targeted in severe infections. Fluoxetine treatment resulted in a decrease in viral protein expression. Fluoxetine is a racemate consisting of both stereoisomers, while the S-form is the dominant serotonin reuptake inhibitor. We found that both isomers show similar activity on the virus, indicating that the R-form might specifically be used for SARS-CoV-2 treatment. Fluoxetine inhibited neither Rabies virus, human respiratory syncytial virus replication nor the Human Herpesvirus 8 or Herpes simplex virus type 1 gene expression, indicating that it acts virus-specific. Moreover, since it is known that Fluoxetine inhibits cytokine release, we see the role of Fluoxetine in the treatment of SARS-CoV-2 infected patients of risk groups. |Animals[MESH] |Antiviral Agents/*pharmacology/therapeutic use[MESH] |COVID-19 Drug Treatment[MESH] |COVID-19/*virology[MESH] |Cell Line[MESH] |Cells, Cultured[MESH] |Fluoxetine/*pharmacology/therapeutic use[MESH] |Humans[MESH] |Lung/*drug effects/pathology/*virology[MESH] |SARS-CoV-2/*drug effects[MESH] |Selective Serotonin Reuptake Inhibitors/*pharmacology/therapeutic use[MESH]The serotonin reuptake inhibitor Fluoxetine inhibits SARS-CoV-2 in hum(epmc).pdf DeepDyve Pubget Overpricing