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Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Sci+Transl+Med 2021 ; 13 (590): ä Nephropedia Template TP
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SARS-CoV-2 infection of human iPSC-derived cardiac cells reflects cytopathic features in hearts of patients with COVID-19 #MMPMID33723017
Perez-Bermejo JA; Kang S; Rockwood SJ; Simoneau CR; Joy DA; Silva AC; Ramadoss GN; Flanigan WR; Fozouni P; Li H; Chen PY; Nakamura K; Whitman JD; Hanson PJ; McManus BM; Ott M; Conklin BR; McDevitt TC
Sci Transl Med 2021[Apr]; 13 (590): ä PMID33723017show ga
Although coronavirus disease 2019 (COVID-19) causes cardiac dysfunction in up to 25% of patients, its pathogenesis remains unclear. Exposure of human induced pluripotent stem cell (iPSC)-derived heart cells to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) revealed productive infection and robust transcriptomic and morphological signatures of damage, particularly in cardiomyocytes. Transcriptomic disruption of structural genes corroborates adverse morphologic features, which included a distinct pattern of myofibrillar fragmentation and nuclear disruption. Human autopsy specimens from patients with COVID-19 reflected similar alterations, particularly sarcomeric fragmentation. These notable cytopathic features in cardiomyocytes provide insights into SARS-CoV-2-induced cardiac damage, offer a platform for discovery of potential therapeutics, and raise concerns about the long-term consequences of COVID-19 in asymptomatic and severe cases.