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COVID-19 and its impact on the cardiovascular system #MMPMID33723014
Khawaja SA; Mohan P; Jabbour R; Bampouri T; Bowsher G; Hassan AMM; Huq F; Baghdasaryan L; Wang B; Sethi A; Sen S; Petraco R; Ruparelia N; Nijjer S; Malik I; Foale R; Bellamy M; Kooner J; Rana B; Cole G; Sutaria N; Kanaganayagam G; Nihoyannopoulos P; Fox K; Plymen C; Pabari P; Howard L; Davies R; Haji G; Lo Giudice F; Kanagaratnam P; Anderson J; Chukwuemeka A; Khamis R; Varnava A; Baker CSR; Francis DP; Asaria P; Al-Lamee R; Mikhail GW
Open Heart 2021[Mar]; 8 (1): ? PMID33723014show ga
OBJECTIVES: The clinical impact of SARS-CoV-2 has varied across countries with varying cardiovascular manifestations. We review the cardiac presentations, in-hospital outcomes and development of cardiovascular complications in the initial cohort of SARS-CoV-2 positive patients at Imperial College Healthcare National Health Service Trust, UK. METHODS: We retrospectively analysed 498 COVID-19 positive adult admissions to our institute from 7 March to 7 April 2020. Patient data were collected for baseline demographics, comorbidities and in-hospital outcomes, especially relating to cardiovascular intervention. RESULTS: Mean age was 67.4+/-16.1 years and 62.2% (n=310) were male. 64.1% (n=319) of our cohort had underlying cardiovascular disease (CVD) with 53.4% (n=266) having hypertension. 43.2%(n=215) developed acute myocardial injury. Mortality was significantly increased in those patients with myocardial injury (47.4% vs 18.4%, p<0.001). Only four COVID-19 patients had invasive coronary angiography, two underwent percutaneous coronary intervention and one required a permanent pacemaker implantation. 7.0% (n=35) of patients had an inpatient echocardiogram. Acute myocardial injury (OR 2.39, 95% CI 1.31 to 4.40, p=0.005) and history of hypertension (OR 1.88, 95% CI 1.01 to 3.55, p=0.049) approximately doubled the odds of in-hospital mortality in patients admitted with COVID-19 after other variables had been controlled for. CONCLUSION: Hypertension, pre-existing CVD and acute myocardial injury were associated with increased in-hospital mortality in our cohort of COVID-19 patients. However, only a low number of patients required invasive cardiac intervention.
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Open+Heart 2021 ; 8 (1): ?
