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10.1016/j.ijrobp.2021.03.022 http://scihub22266oqcxt.onion/10.1016/j.ijrobp.2021.03.022 33722770!7954779!33722770     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Radiat+Oncol+Biol+Phys 2021 ; 110 (5): 1283-1294 Nephropedia Template TP {{tp|p=33722770|t=2021. Low Doses of Radiation Increase the Immunosuppressive Profile of Lung Macrophages During Viral Infection and Pneumonia |pdf=|usr=}}{{33722770}} gab.com Text Low Doses of Radiation Increase the Immunosuppressive Profile of Lung Macrophages During Viral Infection and Pneumonia JO: Int J Radiat Oncol Biol Phys http://www.kidney.de/pget.php?&tw=1&pmid=33722770 #FOAvip PURPOSE: Severe pneumonia and acute respiratory distress syndrome (ARDS) have been described in patients with severe coronavirus disease 2019 (COVID-19). Recently, early clinical data reported the feasibility of low doses of radiation therapy (RT) in the treatment of ARDS in patients with severe COVID-19. However, the involved mechanisms remained unknown. METHODS AND MATERIALS: Here, we used airways-instilled lipopolysaccharide (LPS) and influenza virus (H1N1) as murine models of pneumonia, and toll-like receptor (TLR)-3 stimulation in human lung macrophages. RESULTS: Low doses of RT (0.5-1 Gray) decreased LPS-induced pneumonia, and increased the percentage of nerve- and airway-associated macrophages producing interleukin (IL) 10. During H1N1 viral infection, we observed decreased lung tissue damage and immune cell infiltration in irradiated animals. Low doses of RT increased IL-10 production by infiltrating immune cells into the lung. Irradiation of TLR-3 ligand-stimulated human lung macrophages ex vivo increased IL-10 secretion and decreased interferon gamma production in the culture supernatant. The percentage of human lung macrophages producing IL-6 was also decreased. CONCLUSIONS: Our data highlight a mechanism by which low doses of RT regulate lung inflammation and skew lung macrophages toward an anti-inflammatory profile. These data provide a preclinical mechanistic support to clinical trials evaluating low doses of RT, such as COVID-19-induced ARDS. Twit Text FOAVip Low Doses of Radiation Increase the Immunosuppressive Profile of Lung Macrophages During Viral Infection and Pneumonia ????Int J Radiat Oncol Biol Phys http://www.kidney.de/pget.php?&tw=1&pmid=33722770 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33722770 #FOAvip English Wikipedia <ref>{{Cite pmid|33722770}}</ref> Low Doses of Radiation Increase the Immunosuppressive Profile of Lung Macrophages During Viral Infection and Pneumonia #MMPMID33722770 Meziani L; Robert C; Classe M; Da Costa B; Mondini M; Clemenson C; Alfaro A; Mordant P; Ammari S; Le Goffic R; Deutsch E Int J Radiat Oncol Biol Phys 2021[Aug]; 110 (5): 1283-1294 PMID33722770show ga PURPOSE: Severe pneumonia and acute respiratory distress syndrome (ARDS) have been described in patients with severe coronavirus disease 2019 (COVID-19). Recently, early clinical data reported the feasibility of low doses of radiation therapy (RT) in the treatment of ARDS in patients with severe COVID-19. However, the involved mechanisms remained unknown. METHODS AND MATERIALS: Here, we used airways-instilled lipopolysaccharide (LPS) and influenza virus (H1N1) as murine models of pneumonia, and toll-like receptor (TLR)-3 stimulation in human lung macrophages. RESULTS: Low doses of RT (0.5-1 Gray) decreased LPS-induced pneumonia, and increased the percentage of nerve- and airway-associated macrophages producing interleukin (IL) 10. During H1N1 viral infection, we observed decreased lung tissue damage and immune cell infiltration in irradiated animals. Low doses of RT increased IL-10 production by infiltrating immune cells into the lung. Irradiation of TLR-3 ligand-stimulated human lung macrophages ex vivo increased IL-10 secretion and decreased interferon gamma production in the culture supernatant. The percentage of human lung macrophages producing IL-6 was also decreased. CONCLUSIONS: Our data highlight a mechanism by which low doses of RT regulate lung inflammation and skew lung macrophages toward an anti-inflammatory profile. These data provide a preclinical mechanistic support to clinical trials evaluating low doses of RT, such as COVID-19-induced ARDS. |*Influenza A Virus, H1N1 Subtype/radiation effects[MESH] |Animals[MESH] |Anti-Inflammatory Agents/pharmacology[MESH] |COVID-19/complications[MESH] |Dexamethasone/pharmacology[MESH] |Disease Models, Animal[MESH] |Epithelial Cells/drug effects/immunology/metabolism/*radiation effects[MESH] |Female[MESH] |Flow Cytometry[MESH] |Humans[MESH] |Interferon-gamma/biosynthesis[MESH] |Interleukin-10/*biosynthesis[MESH] |Interleukin-6/biosynthesis[MESH] |Lipopolysaccharides[MESH] |Lung/cytology/pathology/radiation effects[MESH] |Macrophages/drug effects/immunology/metabolism/*radiation effects[MESH] |Mice[MESH] |Mice, Inbred C57BL[MESH] |Pneumonia, Viral/etiology/prevention & control/*radiotherapy[MESH] |Poly I-C[MESH] |Radiotherapy Dosage[MESH] |Respiratory Distress Syndrome/etiology/*radiotherapy[MESH] |Toll-Like Receptor 3[MESH]Low Doses of Radiation Increase the Immunosuppressive Profile of Lung (epmc).pdf DeepDyve Pubget Overpricing