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10.1007/s43630-020-00004-8

http://scihub22266oqcxt.onion/10.1007/s43630-020-00004-8
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33721239!7791943!33721239
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suck abstract from ncbi


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pmid33721239      Photochem+Photobiol+Sci 2021 ; 20 (1): 183-188
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  • COVID-19 and the ethnicity link - is there a photochemical link? #MMPMID33721239
  • Edge R; Truscott TG
  • Photochem Photobiol Sci 2021[Jan]; 20 (1): 183-188 PMID33721239show ga
  • A hypothesis is proposed to explain the increased detrimental effect of COVID-19 for Black, Asian and Minority Ethnic (BAME) men and women compared to Caucasian individuals. This is based on the differing photochemistry of phaeomelanin in fair skin and eumelanin in dark/black skin. It is suggested that a range of reactive oxygen species, including, singlet oxygen and the superoxide radical anion, derived via direct photolysis of phaeomelanin, may escape the melanocyte and cause subsequent damage to the SARS-CoV-2 virus. It is further suggested that (large) carbon and sulphur peroxy radicals, from oxygen addition to radicals formed by carbon-sulphur bond cleavage, may assist via damage to the cell membranes. It is also speculated that light absorption by phaeomelanin and the subsequent C-S bond cleavage, leads to release of pre-absorbed reactive oxygen species, such as singlet oxygen and free radicals, which may also contribute to an enhanced protective effect for fair-skinned people.
  • |*Ethnicity[MESH]
  • |*Photochemical Processes[MESH]
  • |COVID-19/ethnology/*pathology/virology[MESH]
  • |Carbon/chemistry[MESH]
  • |Female[MESH]
  • |Free Radicals/chemistry[MESH]
  • |Humans[MESH]
  • |Light[MESH]
  • |Male[MESH]
  • |Melanins/chemistry[MESH]
  • |Photolysis[MESH]
  • |SARS-CoV-2/isolation & purification[MESH]
  • |Singlet Oxygen/chemistry/metabolism[MESH]
  • |Skin/metabolism[MESH]
  • |Sulfur/chemistry[MESH]


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