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10.1172/jci.insight.146316 http://scihub22266oqcxt.onion/10.1172/jci.insight.146316 33720905!8119195!33720905     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       JCI+Insight 2021 ; 6 (8): ä Nephropedia Template TP {{tp|p=33720905|t=2021. A majority of uninfected adults show preexisting antibody reactivity against SARS-CoV-2 |pdf=|usr=}}{{33720905}} gab.com Text A majority of uninfected adults show preexisting antibody reactivity against SARS-CoV-2 JO: JCI Insight http://www.kidney.de/pget.php?&tw=1&pmid=33720905 #FOAvip Preexisting cross-reactivity to SARS-CoV-2 occurs in the absence of prior viral exposure. However, this has been difficult to quantify at the population level due to a lack of reliably defined seroreactivity thresholds. Using an orthogonal antibody testing approach, we estimated that about 0.6% of nontriaged adults from the greater Vancouver, Canada, area between May 17 and June 19, 2020, showed clear evidence of a prior SARS-CoV-2 infection, after adjusting for false-positive and false-negative test results. Using a highly sensitive multiplex assay and positive/negative thresholds established in infants in whom maternal antibodies have waned, we determined that more than 90% of uninfected adults showed antibody reactivity against the spike protein, receptor-binding domain (RBD), N-terminal domain (NTD), or the nucleocapsid (N) protein from SARS-CoV-2. This seroreactivity was evenly distributed across age and sex, correlated with circulating coronaviruses' reactivity, and was partially outcompeted by soluble circulating coronaviruses' spike. Using a custom SARS-CoV-2 peptide mapping array, we found that this antibody reactivity broadly mapped to spike and to conserved nonstructural viral proteins. We conclude that most adults display preexisting antibody cross-reactivity against SARS-CoV-2, which further supports investigation of how this may impact the clinical severity of COVID-19 or SARS-CoV-2 vaccine responses. Twit Text FOAVip A majority of uninfected adults show preexisting antibody reactivity against SARS-CoV-2 ????JCI Insight http://www.kidney.de/pget.php?&tw=1&pmid=33720905 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33720905 #FOAvip English Wikipedia <ref>{{Cite pmid|33720905}}</ref> A majority of uninfected adults show preexisting antibody reactivity against SARS-CoV-2 #MMPMID33720905 Majdoubi A; Michalski C; O'Connell SE; Dada S; Narpala S; Gelinas J; Mehta D; Cheung C; Winkler DF; Basappa M; Liu AC; Gorges M; Barakauskas VE; Irvine M; Mehalko J; Esposito D; Sekirov I; Jassem AN; Goldfarb DM; Pelech S; Douek DC; McDermott AB; Lavoie PM JCI Insight 2021[Apr]; 6 (8): ä PMID33720905show ga Preexisting cross-reactivity to SARS-CoV-2 occurs in the absence of prior viral exposure. However, this has been difficult to quantify at the population level due to a lack of reliably defined seroreactivity thresholds. Using an orthogonal antibody testing approach, we estimated that about 0.6% of nontriaged adults from the greater Vancouver, Canada, area between May 17 and June 19, 2020, showed clear evidence of a prior SARS-CoV-2 infection, after adjusting for false-positive and false-negative test results. Using a highly sensitive multiplex assay and positive/negative thresholds established in infants in whom maternal antibodies have waned, we determined that more than 90% of uninfected adults showed antibody reactivity against the spike protein, receptor-binding domain (RBD), N-terminal domain (NTD), or the nucleocapsid (N) protein from SARS-CoV-2. This seroreactivity was evenly distributed across age and sex, correlated with circulating coronaviruses' reactivity, and was partially outcompeted by soluble circulating coronaviruses' spike. Using a custom SARS-CoV-2 peptide mapping array, we found that this antibody reactivity broadly mapped to spike and to conserved nonstructural viral proteins. We conclude that most adults display preexisting antibody cross-reactivity against SARS-CoV-2, which further supports investigation of how this may impact the clinical severity of COVID-19 or SARS-CoV-2 vaccine responses. |Adult[MESH] |Antibodies, Neutralizing/*blood/immunology[MESH] |Antibodies, Viral/*blood/immunology[MESH] |Antigens, Viral/*immunology[MESH] |British Columbia/epidemiology[MESH] |COVID-19 Serological Testing/statistics & numerical data[MESH] |COVID-19 Vaccines/administration & dosage[MESH] |COVID-19/blood/diagnosis/*immunology/prevention & control[MESH] |Cross Reactions/immunology[MESH] |Cross-Sectional Studies[MESH] |Female[MESH] |Geography[MESH] |Healthy Volunteers[MESH] |Humans[MESH] |Immunity, Humoral[MESH] |Immunoassay/statistics & numerical data[MESH] |Male[MESH] |Middle Aged[MESH] |Prospective Studies[MESH] |SARS-CoV-2/*immunology/isolation & purification[MESH]A majority of uninfected adults show preexisting antibody reactivity a(epmc).pdf DeepDyve Pubget Overpricing