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10.1080/14787210.2021.1902805

http://scihub22266oqcxt.onion/10.1080/14787210.2021.1902805
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33719819!ä!33719819

suck abstract from ncbi


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pmid33719819      Expert+Rev+Anti+Infect+Ther 2021 ; 19 (10): 1219-1244
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  • Pharmacological interventions for COVID-19: a systematic review of observational studies and clinical trials #MMPMID33719819
  • Bokharee N; Khan YH; Khokhar A; Mallhi TH; Alotaibi NH; Rasheed M
  • Expert Rev Anti Infect Ther 2021[Oct]; 19 (10): 1219-1244 PMID33719819show ga
  • Introduction: Currently, there is no approved therapeutic entity for coronavirus disease 2019 (COVID-19) and clinicians are primarily relying on drug repurposing. However, findings across studies are widely disparate, making it difficult to draw firm conclusions. Since clinicians need accurate evidence to treat COVID-19, this manuscript systematically analyzed the published and ongoing studies evaluating the pharmacological interventions for COVID-19.Areas Covered: A systematic search of observational studies and Clinical Trials on the treatment and prevention of COVID-19 was performed by using various databases from inception to 2 December 2020.Expert Opinion: A total of 460 studies met the inclusion criteria. Of these, 37 were research studies, 386 were ongoing trials, and 37 were completed trials. Anti-virals, steroids, anti-malarial, plasma exchange, and monoclonal antibodies were the most common treatment modalities used alone or in combination in these studies. However, tocilizumab, plasma exchange, and steroids have shown significant improvements in patient's clinical and radiological status. Tocilizumab reported minimum hospital stay of 2 days along with maximum recovery and patient's stability rate. Existing literature demonstrate promising results of tocilizumab, plasma exchange, and steroids among COVID-19 patients. Nevertheless, these studies are accompanied by several methodological disparities which should be considered while interpreting the results.
  • |*COVID-19 Drug Treatment[MESH]
  • |Adenosine Monophosphate/analogs & derivatives/therapeutic use[MESH]
  • |Alanine/analogs & derivatives/therapeutic use[MESH]
  • |Amides/therapeutic use[MESH]
  • |Anti-Inflammatory Agents/*therapeutic use[MESH]
  • |Antibodies, Monoclonal, Humanized/therapeutic use[MESH]
  • |Antimalarials/therapeutic use[MESH]
  • |Antiviral Agents/*therapeutic use[MESH]
  • |COVID-19 Serotherapy[MESH]
  • |COVID-19/mortality/therapy[MESH]
  • |Chloroquine/therapeutic use[MESH]
  • |Clinical Trials as Topic[MESH]
  • |Humans[MESH]
  • |Hydroxychloroquine/therapeutic use[MESH]
  • |Immunization, Passive[MESH]
  • |Indoles/therapeutic use[MESH]
  • |Intensive Care Units[MESH]
  • |Length of Stay[MESH]
  • |Lopinavir/therapeutic use[MESH]
  • |Methylprednisolone/*therapeutic use[MESH]
  • |Observational Studies as Topic[MESH]
  • |Patient Admission/statistics & numerical data[MESH]
  • |Pyrazines/therapeutic use[MESH]
  • |Ritonavir/therapeutic use[MESH]
  • |SARS-CoV-2[MESH]


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