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10.3389/fimmu.2021.640644 http://scihub22266oqcxt.onion/10.3389/fimmu.2021.640644 33717195!7953065!33717195     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Immunol 2021 ; 12 (ä): 640644 Nephropedia Template TP {{tp|p=33717195|t=2021. COVID-19 Impairs Immune Response to Candida albicans |pdf=|usr=}}{{33717195}} gab.com Text COVID-19 Impairs Immune Response to Candida albicans JO: Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=33717195 #FOAvip Infection with SARS-CoV-2 can lead to Coronavirus disease-2019 (COVID-19) and result in severe acute respiratory distress syndrome (ARDS). Recent reports indicate an increased rate of fungal coinfections during COVID-19. With incomplete understanding of the pathogenesis and without any causative therapy available, secondary infections may be detrimental to the prognosis. We monitored 11 COVID-19 patients with ARDS for their immune phenotype, plasma cytokines, and clinical parameters on the day of ICU admission and on day 4 and day 7 of their ICU stay. Whole blood stimulation assays with lipopolysaccharide (LPS), heat-killed Listeria monocytogenes (HKLM), Aspergillus fumigatus, and Candida albicans were used to mimic secondary infections, and changes in immune phenotype and cytokine release were assessed. COVID-19 patients displayed an immune phenotype characterized by increased HLA-DR(+)CD38(+) and PD-1(+) CD4(+) and CD8(+) T cells, and elevated CD8(+)CD244(+) lymphocytes, compared to healthy controls. Monocyte activation markers and cytokines IL-6, IL-8, TNF, IL-10, and sIL2Ralpha were elevated, corresponding to monocyte activation syndrome, while IL-1beta levels were low. LPS, HKLM and Aspergillus fumigatus antigen stimulation provoked an immune response that did not differ between COVID-19 patients and healthy controls, while COVID-19 patients showed an attenuated monocyte CD80 upregulation and abrogated release of IL-6, TNF, IL-1alpha, and IL-1beta toward Candida albicans. This study adds further detail to the characterization of the immune response in critically ill COVID-19 patients and hints at an increased susceptibility for Candida albicans infection. Twit Text FOAVip COVID-19 Impairs Immune Response to Candida albicans ????Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=33717195 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33717195 #FOAvip English Wikipedia <ref>{{Cite pmid|33717195}}</ref> COVID-19 Impairs Immune Response to Candida albicans #MMPMID33717195 Moser D; Biere K; Han B; Hoerl M; Schelling G; Chouker A; Woehrle T Front Immunol 2021[]; 12 (ä): 640644 PMID33717195show ga Infection with SARS-CoV-2 can lead to Coronavirus disease-2019 (COVID-19) and result in severe acute respiratory distress syndrome (ARDS). Recent reports indicate an increased rate of fungal coinfections during COVID-19. With incomplete understanding of the pathogenesis and without any causative therapy available, secondary infections may be detrimental to the prognosis. We monitored 11 COVID-19 patients with ARDS for their immune phenotype, plasma cytokines, and clinical parameters on the day of ICU admission and on day 4 and day 7 of their ICU stay. Whole blood stimulation assays with lipopolysaccharide (LPS), heat-killed Listeria monocytogenes (HKLM), Aspergillus fumigatus, and Candida albicans were used to mimic secondary infections, and changes in immune phenotype and cytokine release were assessed. COVID-19 patients displayed an immune phenotype characterized by increased HLA-DR(+)CD38(+) and PD-1(+) CD4(+) and CD8(+) T cells, and elevated CD8(+)CD244(+) lymphocytes, compared to healthy controls. Monocyte activation markers and cytokines IL-6, IL-8, TNF, IL-10, and sIL2Ralpha were elevated, corresponding to monocyte activation syndrome, while IL-1beta levels were low. LPS, HKLM and Aspergillus fumigatus antigen stimulation provoked an immune response that did not differ between COVID-19 patients and healthy controls, while COVID-19 patients showed an attenuated monocyte CD80 upregulation and abrogated release of IL-6, TNF, IL-1alpha, and IL-1beta toward Candida albicans. This study adds further detail to the characterization of the immune response in critically ill COVID-19 patients and hints at an increased susceptibility for Candida albicans infection. |Aged[MESH] |Aspergillus fumigatus/*immunology[MESH] |CD4-Positive T-Lymphocytes/*immunology[MESH] |CD8-Positive T-Lymphocytes/*immunology[MESH] |COVID-19/*immunology[MESH] |Candida albicans/*immunology[MESH] |Cells, Cultured[MESH] |Cytokines/metabolism[MESH] |Disease Susceptibility[MESH] |Female[MESH] |Humans[MESH] |Immune Tolerance[MESH] |Listeria monocytogenes/*immunology[MESH] |Male[MESH] |Middle Aged[MESH] |Programmed Cell Death 1 Receptor/metabolism[MESH] |Respiratory Distress Syndrome[MESH]COVID-19 Impairs Immune Response to Candida albicans (epmc).pdf DeepDyve Pubget Overpricing