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10.18632/aging.202691 http://scihub22266oqcxt.onion/10.18632/aging.202691 33714947!8034949!33714947     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 286.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 286.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 286.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 286.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 286.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 286.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 320.4 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Aging+(Albany+NY) 2021 ; 13 (6): 7713-7722 Nephropedia Template TP {{tp|p=33714947|t=2021. Age cohorts stratified according to age-distributions of COVID-19 morbidity statistics identify uniquely age-dependent CD3(+)CD8(+) T-cell lymphocytopenia in COVID-19 patients without comorbidities on admission |pdf=|usr=}}{{33714947}} gab.com Text Age cohorts stratified according to age-distributions of COVID-19 morbidity statistics identify uniquely age-dependent CD3(+)CD8(+) T-cell lymphocytopenia in COVID-19 patients without comorbidities on admission JO: Aging (Albany NY) http://www.kidney.de/pget.php?&tw=1&pmid=33714947 #FOAvip If age boundaries are arbitrarily or roughly defined, age-related analyses can result in questionable findings. Here, we aimed to delineate the uniquely age-dependent immune features of coronavirus disease 2019 (COVID-19) in a retrospective study of 447 patients, stratified according to age distributions of COVID-19 morbidity statistics into well-defined age-cohorts (2-25y, 26-38y, 39-57y, 58-68y, and 69-79y). Age-dependent susceptibilities and severities of the disease were observed in COVID-19 patients. A comparison of the lymphocyte counts among the five age-groups indicated that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection led to age-dependent lymphopenia. Among the lymphocyte subsets, the CD8(+) T cell count alone was significantly and age-dependently decreased (520, 385, 320, 172, and 139 n/mul in the five age-groups, respectively). In contrast, the CD4(+) T cell, B cell, and natural killer cell counts did not differ among age-cohorts. Age and CD8(+) T cell counts (r=?0.435, p<0.0001) were negatively correlated in COVID-19 patients. Moreover, SARS-CoV-2 infection age-dependently increased the plasma C-reactive protein concentrations (2.0, 5.0, 9.0, 11.6, and 36.1 mg/L in the five age-groups, respectively). These findings can be used to elucidate the role of CD8(+) T cells in age-related pathogenesis and to help develop therapeutic strategies for COVID-19. Twit Text FOAVip Age cohorts stratified according to age-distributions of COVID-19 morbidity statistics identify uniquely age-dependent CD3(+)CD8(+) T-cell lymphocytopenia in COVID-19 patients without comorbidities on admission ????Aging (Albany NY) http://www.kidney.de/pget.php?&tw=1&pmid=33714947 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33714947 #FOAvip English Wikipedia <ref>{{Cite pmid|33714947}}</ref> Age cohorts stratified according to age-distributions of COVID-19 morbidity statistics identify uniquely age-dependent CD3(+)CD8(+) T-cell lymphocytopenia in COVID-19 patients without comorbidities on admission #MMPMID33714947 Jin S; An H; Zhou T; Li T; Chen C; Ying B; Xu Z; Li X; Li M Aging (Albany NY) 2021[Mar]; 13 (6): 7713-7722 PMID33714947show ga If age boundaries are arbitrarily or roughly defined, age-related analyses can result in questionable findings. Here, we aimed to delineate the uniquely age-dependent immune features of coronavirus disease 2019 (COVID-19) in a retrospective study of 447 patients, stratified according to age distributions of COVID-19 morbidity statistics into well-defined age-cohorts (2-25y, 26-38y, 39-57y, 58-68y, and 69-79y). Age-dependent susceptibilities and severities of the disease were observed in COVID-19 patients. A comparison of the lymphocyte counts among the five age-groups indicated that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection led to age-dependent lymphopenia. Among the lymphocyte subsets, the CD8(+) T cell count alone was significantly and age-dependently decreased (520, 385, 320, 172, and 139 n/mul in the five age-groups, respectively). In contrast, the CD4(+) T cell, B cell, and natural killer cell counts did not differ among age-cohorts. Age and CD8(+) T cell counts (r=?0.435, p<0.0001) were negatively correlated in COVID-19 patients. Moreover, SARS-CoV-2 infection age-dependently increased the plasma C-reactive protein concentrations (2.0, 5.0, 9.0, 11.6, and 36.1 mg/L in the five age-groups, respectively). These findings can be used to elucidate the role of CD8(+) T cells in age-related pathogenesis and to help develop therapeutic strategies for COVID-19. |*Age Distribution[MESH] |*Patient Admission[MESH] |Adolescent[MESH] |Adult[MESH] |Aged[MESH] |CD3 Complex/*immunology[MESH] |CD8-Positive T-Lymphocytes/*immunology[MESH] |COVID-19/*complications/virology[MESH] |Child[MESH] |Child, Preschool[MESH] |Cohort Studies[MESH] |Female[MESH] |Humans[MESH] |Lymphocyte Count[MESH] |Lymphopenia/*complications/immunology[MESH] |Male[MESH] |Middle Aged[MESH] |Retrospective Studies[MESH] |SARS-CoV-2/isolation & purification[MESH]Age cohorts stratified according to age-distributions of COVID-19 morb(epmc).pdf DeepDyve Pubget Overpricing