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10.1016/j.cell.2021.02.018 http://scihub22266oqcxt.onion/10.1016/j.cell.2021.02.018 33713619!7874909!33713619     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell 2021 ; 184 (7): 1836-1857.e22 Nephropedia Template TP {{tp|p=33713619|t=2021. Time-resolved systems immunology reveals a late juncture linked to fatal COVID-19 |pdf=|usr=}}{{33713619}} gab.com Text Time-resolved systems immunology reveals a late juncture linked to fatal COVID-19 JO: Cell http://www.kidney.de/pget.php?&tw=1&pmid=33713619 #FOAvip COVID-19 exhibits extensive patient-to-patient heterogeneity. To link immune response variation to disease severity and outcome over time, we longitudinally assessed circulating proteins as well as 188 surface protein markers, transcriptome, and T cell receptor sequence simultaneously in single peripheral immune cells from COVID-19 patients. Conditional-independence network analysis revealed primary correlates of disease severity, including gene expression signatures of apoptosis in plasmacytoid dendritic cells and attenuated inflammation but increased fatty acid metabolism in CD56(dim)CD16(hi) NK cells linked positively to circulating interleukin (IL)-15. CD8(+) T cell activation was apparent without signs of exhaustion. Although cellular inflammation was depressed in severe patients early after hospitalization, it became elevated by days 17-23 post symptom onset, suggestive of a late wave of inflammatory responses. Furthermore, circulating protein trajectories at this time were divergent between and predictive of recovery versus fatal outcomes. Our findings stress the importance of timing in the analysis, clinical monitoring, and therapeutic intervention of COVID-19. Twit Text FOAVip Time-resolved systems immunology reveals a late juncture linked to fatal COVID-19 ????Cell http://www.kidney.de/pget.php?&tw=1&pmid=33713619 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33713619 #FOAvip English Wikipedia <ref>{{Cite pmid|33713619}}</ref> Time-resolved systems immunology reveals a late juncture linked to fatal COVID-19 #MMPMID33713619 Liu C; Martins AJ; Lau WW; Rachmaninoff N; Chen J; Imberti L; Mostaghimi D; Fink DL; Burbelo PD; Dobbs K; Delmonte OM; Bansal N; Failla L; Sottini A; Quiros-Roldan E; Han KL; Sellers BA; Cheung F; Sparks R; Chun TW; Moir S; Lionakis MS; Rossi C; Su HC; Kuhns DB; Cohen JI; Notarangelo LD; Tsang JS Cell 2021[Apr]; 184 (7): 1836-1857.e22 PMID33713619show ga COVID-19 exhibits extensive patient-to-patient heterogeneity. To link immune response variation to disease severity and outcome over time, we longitudinally assessed circulating proteins as well as 188 surface protein markers, transcriptome, and T cell receptor sequence simultaneously in single peripheral immune cells from COVID-19 patients. Conditional-independence network analysis revealed primary correlates of disease severity, including gene expression signatures of apoptosis in plasmacytoid dendritic cells and attenuated inflammation but increased fatty acid metabolism in CD56(dim)CD16(hi) NK cells linked positively to circulating interleukin (IL)-15. CD8(+) T cell activation was apparent without signs of exhaustion. Although cellular inflammation was depressed in severe patients early after hospitalization, it became elevated by days 17-23 post symptom onset, suggestive of a late wave of inflammatory responses. Furthermore, circulating protein trajectories at this time were divergent between and predictive of recovery versus fatal outcomes. Our findings stress the importance of timing in the analysis, clinical monitoring, and therapeutic intervention of COVID-19. |*Severity of Illness Index[MESH] |Adult[MESH] |Aged[MESH] |Aged, 80 and over[MESH] |Biomarkers/metabolism[MESH] |COVID-19/*immunology/mortality[MESH] |Case-Control Studies[MESH] |Cytokines/*metabolism[MESH] |Dendritic Cells/cytology/*metabolism[MESH] |Female[MESH] |Gene Expression/*immunology[MESH] |Humans[MESH] |Killer Cells, Natural/cytology/*metabolism[MESH] |Longitudinal Studies[MESH] |Male[MESH] |Middle Aged[MESH] |Transcriptome/immunology[MESH]Time-resolved systems immunology reveals a late juncture linked to fat(epmc).pdf DeepDyve Pubget Overpricing