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10.1210/clinem/dgab148 http://scihub22266oqcxt.onion/10.1210/clinem/dgab148 33713408!7989224!33713408     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Clin+Endocrinol+Metab 2021 ; 106 (7): 1994-2009 Nephropedia Template TP {{tp|p=33713408|t=2021. The Association of TSH and Thyroid Hormones With Lymphopenia in Bacterial Sepsis and COVID-19 |pdf=|usr=}}{{33713408}} gab.com Text The Association of TSH and Thyroid Hormones With Lymphopenia in Bacterial Sepsis and COVID-19 JO: J Clin Endocrinol Metab http://www.kidney.de/pget.php?&tw=1&pmid=33713408 #FOAvip CONTEXT: Lymphopenia is a key feature of immune dysfunction in patients with bacterial sepsis and coronavirus disease 2019 (COVID-19) and is associated with poor clinical outcomes, but the cause is largely unknown. Severely ill patients may present with thyroid function abnormalities, so-called nonthyroidal illness syndrome, and several studies have linked thyrotropin (thyroid stimulating hormone, TSH) and the thyroid hormones thyroxine (T4) and 3,5,3'-triiodothyronine (T3) to homeostatic regulation and function of lymphocyte populations. OBJECTIVE: This work aimed to test the hypothesis that abnormal thyroid function correlates with lymphopenia in patients with severe infections. METHODS: A retrospective analysis of absolute lymphocyte counts, circulating TSH, T4, free T4 (FT4), T3, albumin, and inflammatory biomarkers was performed in 2 independent hospitalized study populations: bacterial sepsis (n = 224) and COVID-19 patients (n = 161). A subgroup analysis was performed in patients with severe lymphopenia and normal lymphocyte counts. RESULTS: Only T3 significantly correlated (rho = 0.252) with lymphocyte counts in patients with bacterial sepsis, and lower concentrations were found in severe lymphopenic compared to nonlymphopenic patients (n = 56 per group). Severe lymphopenic COVID-19 patients (n = 17) showed significantly lower plasma concentrations of TSH, T4, FT4, and T3 compared to patients without lymphopenia (n = 18), and demonstrated significantly increased values of the inflammatory markers interleukin-6, C-reactive protein, and ferritin. Remarkably, after 1 week of follow-up, the majority (12 of 15) of COVID-19 patients showed quantitative recovery of their lymphocyte numbers, whereas TSH and thyroid hormones remained mainly disturbed. CONCLUSION: Abnormal thyroid function correlates with lymphopenia in patients with severe infections, like bacterial sepsis and COVID-19, but future studies need to establish whether a causal relationship is involved. Twit Text FOAVip The Association of TSH and Thyroid Hormones With Lymphopenia in Bacterial Sepsis and COVID-19 ????J Clin Endocrinol Metab http://www.kidney.de/pget.php?&tw=1&pmid=33713408 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33713408 #FOAvip English Wikipedia <ref>{{Cite pmid|33713408}}</ref> The Association of TSH and Thyroid Hormones With Lymphopenia in Bacterial Sepsis and COVID-19 #MMPMID33713408 Grondman I; de Nooijer AH; Antonakos N; Janssen NAF; Mouktaroudi M; Leventogiannis K; Medici M; Smit JWA; van Herwaarden AE; Joosten LAB; van de Veerdonk FL; Pickkers P; Kox M; Jaeger M; Netea MG; Giamarellos-Bourboulis EJ; Netea-Maier RT J Clin Endocrinol Metab 2021[Jun]; 106 (7): 1994-2009 PMID33713408show ga CONTEXT: Lymphopenia is a key feature of immune dysfunction in patients with bacterial sepsis and coronavirus disease 2019 (COVID-19) and is associated with poor clinical outcomes, but the cause is largely unknown. Severely ill patients may present with thyroid function abnormalities, so-called nonthyroidal illness syndrome, and several studies have linked thyrotropin (thyroid stimulating hormone, TSH) and the thyroid hormones thyroxine (T4) and 3,5,3'-triiodothyronine (T3) to homeostatic regulation and function of lymphocyte populations. OBJECTIVE: This work aimed to test the hypothesis that abnormal thyroid function correlates with lymphopenia in patients with severe infections. METHODS: A retrospective analysis of absolute lymphocyte counts, circulating TSH, T4, free T4 (FT4), T3, albumin, and inflammatory biomarkers was performed in 2 independent hospitalized study populations: bacterial sepsis (n = 224) and COVID-19 patients (n = 161). A subgroup analysis was performed in patients with severe lymphopenia and normal lymphocyte counts. RESULTS: Only T3 significantly correlated (rho = 0.252) with lymphocyte counts in patients with bacterial sepsis, and lower concentrations were found in severe lymphopenic compared to nonlymphopenic patients (n = 56 per group). Severe lymphopenic COVID-19 patients (n = 17) showed significantly lower plasma concentrations of TSH, T4, FT4, and T3 compared to patients without lymphopenia (n = 18), and demonstrated significantly increased values of the inflammatory markers interleukin-6, C-reactive protein, and ferritin. Remarkably, after 1 week of follow-up, the majority (12 of 15) of COVID-19 patients showed quantitative recovery of their lymphocyte numbers, whereas TSH and thyroid hormones remained mainly disturbed. CONCLUSION: Abnormal thyroid function correlates with lymphopenia in patients with severe infections, like bacterial sepsis and COVID-19, but future studies need to establish whether a causal relationship is involved. |Aged[MESH] |Aged, 80 and over[MESH] |COVID-19/blood/*complications/immunology[MESH] |Euthyroid Sick Syndromes/blood/*diagnosis/immunology[MESH] |Female[MESH] |Greece[MESH] |Humans[MESH] |Lymphocyte Count[MESH] |Lymphopenia/blood/diagnosis/*immunology[MESH] |Male[MESH] |Netherlands[MESH] |Retrospective Studies[MESH] |SARS-CoV-2/immunology[MESH] |Sepsis/blood/*complications/immunology[MESH] |Thyroid Hormones/blood/immunology[MESH]The Association of TSH and Thyroid Hormones With Lymphopenia in Bacter(epmc).pdf DeepDyve Pubget Overpricing