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http://scihub22266oqcxt.onion/ 33713098!ä!33713098 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Pol+Merkur+Lekarski 2021 ; 49 (289): 67-70 Nephropedia Template TP {{tp|p=33713098|t=2021. Przeciwzapalne dzialanie amantadyny i memantyny w zakazeniu SARS-CoV-2 |pdf=|usr=}}{{33713098}} gab.com Text Przeciwzapalne dzialanie amantadyny i memantyny w zakazeniu SARS-CoV-2 JO: Pol Merkur Lekarski http://www.kidney.de/pget.php?&tw=1&pmid=33713098 #FOAvip Amantadine and memantine, apart from their action on cholinergic receptors and dopamine secretion, have a significant influence on the inflammatory process, including the so-called "cytokine storm" and reduction of apoptosis and oxidative stress. Amantadine also inhibits the induction of inflammatory factors such as RANTES, activates kinase p38 of mitogen-activated protein (MAP) and c-Jun-NH2-terminal kinases (JNK), which inhibit viral replication. It also significantly inhibits the entry of SARS-CoV-2 into the bronchial epithelial cell and blocks the viroporin proton channel of the virus. In addition, it has the ability to pass through the membrane of lysosomes into their interior and act as an alkalizing agent, which prevents the release of viral RNA into the cell, which may be a key element in therapeutic management. Memantine also reduces inflammation, mainly in the nervous system, but also acts as a lysosomotropic factor, inhibiting viral replication. However, it is important to bear in mind when undertaking amantadine or memantine therapy with side effects that may overlap with COVID- 19 symptoms, worsening the condition of patients. Currently, the effectiveness of amantadine and memantine in the treatment of patients with COVID-19 symptoms has been demonstrated in a few clinical trials, mainly in patients treated for neurodegenerative diseases. The obtained results are of considerable value, but require confirmation in further studies. Twit Text FOAVip Przeciwzapalne dzialanie amantadyny i memantyny w zakazeniu SARS-CoV-2 ????Pol Merkur Lekarski http://www.kidney.de/pget.php?&tw=1&pmid=33713098 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33713098 #FOAvip English Wikipedia <ref>{{Cite pmid|33713098}}</ref> Przeciwzapalne dzialanie amantadyny i memantyny w zakazeniu SARS-CoV-2 #MMPMID33713098 Plusa T Pol Merkur Lekarski 2021[Feb]; 49 (289): 67-70 PMID33713098show ga Amantadine and memantine, apart from their action on cholinergic receptors and dopamine secretion, have a significant influence on the inflammatory process, including the so-called "cytokine storm" and reduction of apoptosis and oxidative stress. Amantadine also inhibits the induction of inflammatory factors such as RANTES, activates kinase p38 of mitogen-activated protein (MAP) and c-Jun-NH2-terminal kinases (JNK), which inhibit viral replication. It also significantly inhibits the entry of SARS-CoV-2 into the bronchial epithelial cell and blocks the viroporin proton channel of the virus. In addition, it has the ability to pass through the membrane of lysosomes into their interior and act as an alkalizing agent, which prevents the release of viral RNA into the cell, which may be a key element in therapeutic management. Memantine also reduces inflammation, mainly in the nervous system, but also acts as a lysosomotropic factor, inhibiting viral replication. However, it is important to bear in mind when undertaking amantadine or memantine therapy with side effects that may overlap with COVID- 19 symptoms, worsening the condition of patients. Currently, the effectiveness of amantadine and memantine in the treatment of patients with COVID-19 symptoms has been demonstrated in a few clinical trials, mainly in patients treated for neurodegenerative diseases. The obtained results are of considerable value, but require confirmation in further studies. |*COVID-19[MESH] |*Memantine/pharmacology/therapeutic use[MESH] |Amantadine/pharmacology/therapeutic use[MESH] |Anti-Inflammatory Agents[MESH] |Humans[MESH]Przeciwzapalne dzialanie amantadyny i memantyny w zakazeniu SARS-CoV-2(epmc).pdf DeepDyve Pubget Overpricing