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10.1038/s41598-021-85247-w http://scihub22266oqcxt.onion/10.1038/s41598-021-85247-w 33712679!7955061!33712679     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2021 ; 11 (1): 5860 Nephropedia Template TP {{tp|p=33712679|t=2021. Point-of-care SARS-CoV-2 serological assays for enhanced case finding in a UK inpatient population |pdf=|usr=}}{{33712679}} gab.com Text Point-of-care SARS-CoV-2 serological assays for enhanced case finding in a UK inpatient population JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=33712679 #FOAvip Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) has become a global pandemic. Case identification is currently made by real-time polymerase chain reaction (PCR) during the acute phase and largely restricted to healthcare laboratories. Serological assays are emerging but independent validation is urgently required to assess their utility. We evaluated five different point-of-care (POC) SARS-CoV-2 antibody test kits against PCR, finding concordance across the assays (n = 15). We subsequently tested 200 patients using the OrientGene COVID-19 IgG/IgM Rapid Test Cassette and find a sensitivity of 74% in the early infection period (day 5-9 post symptom onset), with 100% sensitivity not seen until day 13, demonstrating inferiority to PCR testing in the infectious period. Negative rate was 96%, but in validating the serological tests uncovered potential false-negatives from PCR testing late-presenting cases. A positive predictive value (PPV) of 37% in the general population precludes any use for general screening. Where a case definition is applied however, the PPV is substantially improved (95.4%), supporting use of serology testing in carefully targeted, high-risk populations. Larger studies in specific patient cohorts, including those with mild infection are urgently required to inform on the applicability of POC serological assays to help control the spread of SARS-CoV-2 and improve case finding of patients that may experience late complications. Twit Text FOAVip Point-of-care SARS-CoV-2 serological assays for enhanced case finding in a UK inpatient population ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=33712679 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33712679 #FOAvip English Wikipedia <ref>{{Cite pmid|33712679}}</ref> Point-of-care SARS-CoV-2 serological assays for enhanced case finding in a UK inpatient population #MMPMID33712679 Pallett SJC; Denny SJ; Patel A; Charani E; Mughal N; Stebbing J; Davies GW; Moore LSP Sci Rep 2021[Mar]; 11 (1): 5860 PMID33712679show ga Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) has become a global pandemic. Case identification is currently made by real-time polymerase chain reaction (PCR) during the acute phase and largely restricted to healthcare laboratories. Serological assays are emerging but independent validation is urgently required to assess their utility. We evaluated five different point-of-care (POC) SARS-CoV-2 antibody test kits against PCR, finding concordance across the assays (n = 15). We subsequently tested 200 patients using the OrientGene COVID-19 IgG/IgM Rapid Test Cassette and find a sensitivity of 74% in the early infection period (day 5-9 post symptom onset), with 100% sensitivity not seen until day 13, demonstrating inferiority to PCR testing in the infectious period. Negative rate was 96%, but in validating the serological tests uncovered potential false-negatives from PCR testing late-presenting cases. A positive predictive value (PPV) of 37% in the general population precludes any use for general screening. Where a case definition is applied however, the PPV is substantially improved (95.4%), supporting use of serology testing in carefully targeted, high-risk populations. Larger studies in specific patient cohorts, including those with mild infection are urgently required to inform on the applicability of POC serological assays to help control the spread of SARS-CoV-2 and improve case finding of patients that may experience late complications. |*COVID-19 Testing/methods[MESH] |*Inpatients[MESH] |*Point-of-Care Testing[MESH] |*SARS-CoV-2/genetics/immunology[MESH] |*Serologic Tests[MESH] |Aged[MESH] |Aged, 80 and over[MESH] |Antibodies, Viral/immunology[MESH] |COVID-19/*diagnosis/epidemiology/*virology[MESH] |Female[MESH] |Humans[MESH] |Immunoglobulin G/immunology[MESH] |Immunoglobulin M/immunology[MESH] |Male[MESH] |Middle Aged[MESH] |Public Health Surveillance[MESH] |Real-Time Polymerase Chain Reaction[MESH] |Reproducibility of Results[MESH]Point-of-care SARS-CoV-2 serological assays for enhanced case finding (epmc).pdf DeepDyve Pubget Overpricing