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10.1038/s41467-021-21907-9 http://scihub22266oqcxt.onion/10.1038/s41467-021-21907-9 33712622!7955129!33712622     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2021 ; 12 (1): 1618 Nephropedia Template TP {{tp|p=33712622|t=2021. Integrated cytokine and metabolite analysis reveals immunometabolic reprogramming in COVID-19 patients with therapeutic implications |pdf=|usr=}}{{33712622}} gab.com Text Integrated cytokine and metabolite analysis reveals immunometabolic reprogramming in COVID-19 patients with therapeutic implications JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=33712622 #FOAvip Cytokine release syndrome (CRS) is a major cause of the multi-organ injury and fatal outcome induced by SARS-CoV-2 infection in severe COVID-19 patients. Metabolism can modulate the immune responses against infectious diseases, yet our understanding remains limited on how host metabolism correlates with inflammatory responses and affects cytokine release in COVID-19 patients. Here we perform both metabolomics and cytokine/chemokine profiling on serum samples from healthy controls, mild and severe COVID-19 patients, and delineate their global metabolic and immune response landscape. Correlation analyses show tight associations between metabolites and proinflammatory cytokines/chemokines, such as IL-6, M-CSF, IL-1alpha, IL-1beta, and imply a potential regulatory crosstalk between arginine, tryptophan, purine metabolism and hyperinflammation. Importantly, we also demonstrate that targeting metabolism markedly modulates the proinflammatory cytokines release by peripheral blood mononuclear cells isolated from SARS-CoV-2-infected rhesus macaques ex vivo, hinting that exploiting metabolic alterations may be a potential strategy for treating fatal CRS in COVID-19. Twit Text FOAVip Integrated cytokine and metabolite analysis reveals immunometabolic reprogramming in COVID-19 patients with therapeutic implications ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=33712622 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33712622 #FOAvip English Wikipedia <ref>{{Cite pmid|33712622}}</ref> Integrated cytokine and metabolite analysis reveals immunometabolic reprogramming in COVID-19 patients with therapeutic implications #MMPMID33712622 Xiao N; Nie M; Pang H; Wang B; Hu J; Meng X; Li K; Ran X; Long Q; Deng H; Chen N; Li S; Tang N; Huang A; Hu Z Nat Commun 2021[Mar]; 12 (1): 1618 PMID33712622show ga Cytokine release syndrome (CRS) is a major cause of the multi-organ injury and fatal outcome induced by SARS-CoV-2 infection in severe COVID-19 patients. Metabolism can modulate the immune responses against infectious diseases, yet our understanding remains limited on how host metabolism correlates with inflammatory responses and affects cytokine release in COVID-19 patients. Here we perform both metabolomics and cytokine/chemokine profiling on serum samples from healthy controls, mild and severe COVID-19 patients, and delineate their global metabolic and immune response landscape. Correlation analyses show tight associations between metabolites and proinflammatory cytokines/chemokines, such as IL-6, M-CSF, IL-1alpha, IL-1beta, and imply a potential regulatory crosstalk between arginine, tryptophan, purine metabolism and hyperinflammation. Importantly, we also demonstrate that targeting metabolism markedly modulates the proinflammatory cytokines release by peripheral blood mononuclear cells isolated from SARS-CoV-2-infected rhesus macaques ex vivo, hinting that exploiting metabolic alterations may be a potential strategy for treating fatal CRS in COVID-19. |*Metabolome[MESH] |*SARS-CoV-2[MESH] |Animals[MESH] |COVID-19/*immunology/*metabolism/therapy[MESH] |Case-Control Studies[MESH] |Cohort Studies[MESH] |Cytokine Release Syndrome/*immunology/*metabolism/therapy[MESH] |Cytokines/*blood[MESH] |Female[MESH] |Follow-Up Studies[MESH] |Humans[MESH] |In Vitro Techniques[MESH] |Inflammation Mediators/blood[MESH] |Leukocytes, Mononuclear/immunology/metabolism[MESH] |Longitudinal Studies[MESH] |Macaca mulatta[MESH] |Male[MESH] |Metabolic Networks and Pathways[MESH]Integrated cytokine and metabolite analysis reveals immunometabolic re(epmc).pdf DeepDyve Pubget Overpricing