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10.1016/j.crad.2021.02.008

http://scihub22266oqcxt.onion/10.1016/j.crad.2021.02.008
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33712292!7906509!33712292
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suck abstract from ncbi


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pmid33712292      Clin+Radiol 2021 ; 76 (5): 391.e33-391.e41
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  • Evaluation of pulmonary ventilation in COVID-19 patients using oxygen-enhanced three-dimensional ultrashort echo time MRI: a preliminary study #MMPMID33712292
  • Zhao F; Zheng L; Shan F; Dai Y; Shen J; Yang S; Shi Y; Xue K; Zhang Z
  • Clin Radiol 2021[May]; 76 (5): 391.e33-391.e41 PMID33712292show ga
  • AIM: To evaluate the lung function of coronavirus disease 2019 (COVID-19) patients using oxygen-enhanced (OE) ultrashort echo time (UTE) MRI. MATERIALS AND METHODS: Forty-nine patients with COVID-19 were included in the study. The OE-MRI was based on a respiratory-gated three-dimensional (3D) radial UTE sequence. For each patient, the percent signal enhancement (PSE) map was calculated using the expression PSE = (S(100%) - S(21%))/S(21%), where S(21%) and S(100%) are signals acquired during room air and 100% oxygen inhalation, respectively. Agreement of lesion detectability between UTE-MRI and computed tomography (CT) was performed using the kappa test. The Mann-Whitney U-test was used to evaluate the difference in the mean PSE between mild-type COVID-19 and common-type COVID-19. Spearman's test was used to assess the relationship between lesion mean PSE and lesion size. Furthermore, the Mann-Whitney U-test was used to evaluate the difference in region of interest (ROI) mean PSE between normal pulmonary parenchyma and lesions. The Kruskal-Wallis test was applied to test the difference in the mean PSE between different lesion types. RESULTS: CT and UTE-MRI reached good agreement in lesion detectability. Ventilation measures in mild-type patients (5.3 +/- 5.5%) were significantly different from those in common-type patients (3 +/- 3.9%). Besides, there was no significant correlation between lesion mean PSE and lesion size. The mean PSE of COVID-19 lesions (3.2 +/- 4.9%) was significantly lower than that of the pulmonary parenchyma (5.4 +/- 3.9%). No significant difference was found among different lesion types. CONCLUSION: OE-UTE-MRI could serve as a promising method for the assessment of lung function or treatment management of COVID-19 patients.
  • |*Pulmonary Ventilation[MESH]
  • |Adolescent[MESH]
  • |Adult[MESH]
  • |Aged[MESH]
  • |COVID-19/*diagnostic imaging/*physiopathology[MESH]
  • |Feasibility Studies[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Imaging, Three-Dimensional[MESH]
  • |Lung/*diagnostic imaging/physiopathology[MESH]
  • |Magnetic Resonance Imaging/*methods[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Oxygen[MESH]
  • |Prospective Studies[MESH]
  • |SARS-CoV-2[MESH]
  • |Severity of Illness Index[MESH]
  • |Tomography, X-Ray Computed[MESH]


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