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10.1016/j.dsx.2021.02.020

http://scihub22266oqcxt.onion/10.1016/j.dsx.2021.02.020
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33711574!7896120!33711574
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suck abstract from ncbi


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pmid33711574      Diabetes+Metab+Syndr 2021 ; 15 (2): 535-541
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  • A systematic review of clinical and laboratory parameters associated with increased severity among COVID-19 patients #MMPMID33711574
  • Mehta AA; Haridas N; Belgundi P; Jose WM
  • Diabetes Metab Syndr 2021[Mar]; 15 (2): 535-541 PMID33711574show ga
  • BACKGROUND AND AIMS: Corona virus disease 2019 (COVID-19) has been an extremely difficult pandemic to contain and it has affected more than 148 countries worldwide. The main aim of this systematic review is to provide a comprehensive summary of clinical and laboratory parameters that are associated with and indicative of increased severity among COVID-19 patients. MATERIAL AND METHODS: All the available data from high-quality research articles relevant to the epidemiology, demographics, trends in hospitalization and outcomes, clinical signs and symptoms, diagnostic methods and treatment methods of COVID-19 were retrieved and evaluated for inclusion. RESULTS: As per our review, the mean age of patients in the severe group was 59.3 years compared to 46.5 years in non severe group. COVID-19 was more severe among men than women. Clinical presentation was variable among different studies. and dyspnea was the factor indicating severe disease. Laboratory parameters associated with increased severity were lymphopenia <0.8 x 10(9)/L, thrombocytopenia 100 x 10(9)/L, leucocytosis TC > 11 x 10(9)/L, procalcitonin >0.5 ng/mL, d dimer >2 mcg/mL, aspartate transaminase elevation >150U/L, LDH >250U/L. CONCLUSION: This systematic review suggests that COVID-19 is a disease with varied clinical presentation and laboratory parameters. The commonest clinical symptoms were fever, cough and dyspnea. The laboratory parameters associated with severe disease were lymphopenia, elevated LDH, D dimer and Procalcitonin.
  • |Aspartate Aminotransferases/*blood[MESH]
  • |COVID-19/*blood/epidemiology/physiopathology[MESH]
  • |Comorbidity[MESH]
  • |Cough/physiopathology[MESH]
  • |Dyspnea/physiopathology[MESH]
  • |Fever/physiopathology[MESH]
  • |Fibrin Fibrinogen Degradation Products/*metabolism[MESH]
  • |Humans[MESH]
  • |L-Lactate Dehydrogenase/*blood[MESH]
  • |Leukocytosis/*blood[MESH]
  • |Lymphopenia/*blood[MESH]
  • |Procalcitonin/*blood[MESH]
  • |Respiration, Artificial[MESH]
  • |Risk Factors[MESH]
  • |SARS-CoV-2[MESH]
  • |Severity of Illness Index[MESH]


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