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10.1016/j.antiviral.2021.105056 http://scihub22266oqcxt.onion/10.1016/j.antiviral.2021.105056 33711336!7943376!33711336     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Antiviral+Res 2021 ; 189 (ä): 105056 Nephropedia Template TP {{tp|p=33711336|t=2021. Emetine suppresses SARS-CoV-2 replication by inhibiting interaction of viral mRNA with eIF4E |pdf=|usr=}}{{33711336}} gab.com Text Emetine suppresses SARS-CoV-2 replication by inhibiting interaction of viral mRNA with eIF4E JO: Antiviral Res http://www.kidney.de/pget.php?&tw=1&pmid=33711336 #FOAvip Emetine is a FDA-approved drug for the treatment of amebiasis. Previously we demonstrated the antiviral efficacy of emetine against some RNA and DNA viruses. In this study, we evaluated the in vitro antiviral efficacy of emetine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and found it to be a low nanomolar (nM) inhibitor. Interestingly, emetine exhibited protective efficacy against lethal challenge with infectious bronchitis virus (IBV; a chicken coronavirus) in the embryonated chicken egg infection model. Emetine treatment led to a decrease in viral RNA and protein synthesis without affecting other steps of viral life cycle such as attachment, entry and budding. In a chromatin immunoprecipitation (CHIP) assay, emetine was shown to disrupt the binding of SARS-CoV-2 mRNA with eIF4E (eukaryotic translation initiation factor 4E, a cellular cap-binding protein required for initiation of protein translation). Further, molecular docking and molecular dynamics simulation studies suggested that emetine may bind to the cap-binding pocket of eIF4E, in a similar conformation as m7-GTP binds. Additionally, SARS-CoV-2 was shown to exploit ERK/MNK1/eIF4E signalling pathway for its effective replication in the target cells. Collectively our results suggest that further detailed evaluation of emetine as a potential treatment for COVID-19 may be warranted. Twit Text FOAVip Emetine suppresses SARS-CoV-2 replication by inhibiting interaction of viral mRNA with eIF4E ????Antiviral Res http://www.kidney.de/pget.php?&tw=1&pmid=33711336 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33711336 #FOAvip English Wikipedia <ref>{{Cite pmid|33711336}}</ref> Emetine suppresses SARS-CoV-2 replication by inhibiting interaction of viral mRNA with eIF4E #MMPMID33711336 Kumar R; Afsar M; Khandelwal N; Chander Y; Riyesh T; Dedar RK; Gulati BR; Pal Y; Barua S; Tripathi BN; Hussain T; Kumar N Antiviral Res 2021[May]; 189 (ä): 105056 PMID33711336show ga Emetine is a FDA-approved drug for the treatment of amebiasis. Previously we demonstrated the antiviral efficacy of emetine against some RNA and DNA viruses. In this study, we evaluated the in vitro antiviral efficacy of emetine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and found it to be a low nanomolar (nM) inhibitor. Interestingly, emetine exhibited protective efficacy against lethal challenge with infectious bronchitis virus (IBV; a chicken coronavirus) in the embryonated chicken egg infection model. Emetine treatment led to a decrease in viral RNA and protein synthesis without affecting other steps of viral life cycle such as attachment, entry and budding. In a chromatin immunoprecipitation (CHIP) assay, emetine was shown to disrupt the binding of SARS-CoV-2 mRNA with eIF4E (eukaryotic translation initiation factor 4E, a cellular cap-binding protein required for initiation of protein translation). Further, molecular docking and molecular dynamics simulation studies suggested that emetine may bind to the cap-binding pocket of eIF4E, in a similar conformation as m7-GTP binds. Additionally, SARS-CoV-2 was shown to exploit ERK/MNK1/eIF4E signalling pathway for its effective replication in the target cells. Collectively our results suggest that further detailed evaluation of emetine as a potential treatment for COVID-19 may be warranted. |*Antiviral Agents/pharmacology/therapeutic use[MESH] |*Emetine/pharmacology/therapeutic use[MESH] |Animals[MESH] |Chick Embryo[MESH] |Chlorocebus aethiops[MESH] |Coronavirus Infections/drug therapy[MESH] |Eukaryotic Initiation Factor-4E/metabolism[MESH] |Infectious bronchitis virus/*drug effects[MESH] |Protein Binding/drug effects[MESH] |RNA, Messenger/metabolism[MESH] |RNA, Viral/*metabolism[MESH] |SARS-CoV-2/*drug effects[MESH] |Signal Transduction[MESH]Emetine suppresses SARS-CoV-2 replication by inhibiting interaction of(epmc).pdf DeepDyve Pubget Overpricing