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10.1002/prp2.743 http://scihub22266oqcxt.onion/10.1002/prp2.743 33710753!7953359!33710753     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Pharmacol+Res+Perspect 2021 ; 9 (2): e00743 Nephropedia Template TP {{tp|p=33710753|t=2021. Hemoadsorption eliminates remdesivir from the circulation: Implications for the treatment of COVID-19 |pdf=|usr=}}{{33710753}} gab.com Text Hemoadsorption eliminates remdesivir from the circulation: Implications for the treatment of COVID-19 JO: Pharmacol Res Perspect http://www.kidney.de/pget.php?&tw=1&pmid=33710753 #FOAvip Both antiviral treatment with remdesivir and hemoadsorption using a CytoSorb((R)) adsorption device are applied in the treatment of severe COVID-19. The CytoSorb((R)) adsorber consists of porous polymer beads that adsorb a broad range of molecules, including cytokines but also several therapeutic drugs. In this study, we evaluated whether remdesivir and its main active metabolite GS-441524 would be adsorbed by CytoSorb((R)) . Serum containing remdesivir or GS-441524 was circulated in a custom-made system containing a CytoSorb((R)) device. Concentrations of remdesivir and GS-441524 before and after the adsorber were analyzed by liquid chromatography-tandem mass spectrometry. Measurements of remdesivir in the outgoing tube after the adsorber indicated almost complete removal of remdesivir by the device. In the reservoir, concentration of remdesivir showed an exponential decay and was not longer detectable after 60 mins. GS-441524 showed a similar exponential decay but, unlike remdesivir, it reached an adsorption-desorption equilibrium at ~48 microg/L. Remdesivir and its main active metabolite GS-441524 are rapidly eliminated from the perfusate by the CytoSorb((R)) adsorber device in vitro. This should be considered in patients for whom both therapies are indicated, and simultaneous application should be avoided. In general, plasma levels of therapeutic drugs should be closely monitored under concurrent CytoSorb((R)) therapy. Twit Text FOAVip Hemoadsorption eliminates remdesivir from the circulation: Implications for the treatment of COVID-19 ????Pharmacol Res Perspect http://www.kidney.de/pget.php?&tw=1&pmid=33710753 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33710753 #FOAvip English Wikipedia <ref>{{Cite pmid|33710753}}</ref> Hemoadsorption eliminates remdesivir from the circulation: Implications for the treatment of COVID-19 #MMPMID33710753 Biever P; Staudacher DL; Sommer MJ; Triebel H; Neukamm MA; Bode C; Supady A; Lother A Pharmacol Res Perspect 2021[Apr]; 9 (2): e00743 PMID33710753show ga Both antiviral treatment with remdesivir and hemoadsorption using a CytoSorb((R)) adsorption device are applied in the treatment of severe COVID-19. The CytoSorb((R)) adsorber consists of porous polymer beads that adsorb a broad range of molecules, including cytokines but also several therapeutic drugs. In this study, we evaluated whether remdesivir and its main active metabolite GS-441524 would be adsorbed by CytoSorb((R)) . Serum containing remdesivir or GS-441524 was circulated in a custom-made system containing a CytoSorb((R)) device. Concentrations of remdesivir and GS-441524 before and after the adsorber were analyzed by liquid chromatography-tandem mass spectrometry. Measurements of remdesivir in the outgoing tube after the adsorber indicated almost complete removal of remdesivir by the device. In the reservoir, concentration of remdesivir showed an exponential decay and was not longer detectable after 60 mins. GS-441524 showed a similar exponential decay but, unlike remdesivir, it reached an adsorption-desorption equilibrium at ~48 microg/L. Remdesivir and its main active metabolite GS-441524 are rapidly eliminated from the perfusate by the CytoSorb((R)) adsorber device in vitro. This should be considered in patients for whom both therapies are indicated, and simultaneous application should be avoided. In general, plasma levels of therapeutic drugs should be closely monitored under concurrent CytoSorb((R)) therapy. |Adenosine Monophosphate/*analogs & derivatives/blood/pharmacokinetics[MESH] |Adenosine/analogs & derivatives[MESH] |Alanine/*analogs & derivatives/blood/pharmacokinetics[MESH] |Blood Chemical Analysis[MESH] |COVID-19/blood/*therapy[MESH] |Chromatography, Liquid[MESH] |Combined Modality Therapy[MESH] |Furans/blood/pharmacokinetics[MESH] |Hemoperfusion/adverse effects/*instrumentation[MESH] |Humans[MESH] |Pyrroles/blood/pharmacokinetics[MESH] |Tandem Mass Spectrometry[MESH]Hemoadsorption eliminates remdesivir from the circulation: Implication(epmc).pdf DeepDyve Pubget Overpricing