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10.1096/fj.202100008 http://scihub22266oqcxt.onion/10.1096/fj.202100008 33710662!8250337!33710662     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       FASEB+J 2021 ; 35 (4): e21384 Nephropedia Template TP {{tp|p=33710662|t=2021. Evidence for CAT gene being functionally involved in the susceptibility of COVID-19 |pdf=|usr=}}{{33710662}} gab.com Text Evidence for CAT gene being functionally involved in the susceptibility of COVID-19 JO: FASEB J http://www.kidney.de/pget.php?&tw=1&pmid=33710662 #FOAvip Novel coronary pneumonia (COVID-19) is a respiratory distress syndrome caused by a new type of coronavirus. Understanding the genetic basis of susceptibility and prognosis to COVID-19 is of great significance to disease prevention, molecular typing, prognosis, and treatment. However, so far, there have been only two genome-wide association studies (GWASs) on the susceptibility of COVID-19. Starting with these reported DNA variants, we found the genes regulated by these variants through cis-eQTL and cis-meQTL acting. We further did a series of bioinformatics analysis on these potential risk genes. The analysis shows that the genetic variants on EHF regulate the expression of its neighbor CAT gene via cis-eQTL. There was significant evidence that CAT and the SARS-CoV-2-related S protein binding protein ACE2 interact with each other. Intracellular localization results showed that CAT and ACE2 proteins both exists in the cell membrane and extracellular area and their interaction could have an impact on the cell invasion ability of S protein. In addition, the expression of these three genes showed a significant positive correlation in the lungs. Based on these results, we propose that CAT plays a crucial intermediary role in binding effectiveness of ACE2, thereby affecting the susceptibility to COVID-19. Twit Text FOAVip Evidence for CAT gene being functionally involved in the susceptibility of COVID-19 ????FASEB J http://www.kidney.de/pget.php?&tw=1&pmid=33710662 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33710662 #FOAvip English Wikipedia <ref>{{Cite pmid|33710662}}</ref> Evidence for CAT gene being functionally involved in the susceptibility of COVID-19 #MMPMID33710662 Qian Y; Li Y; Liu X; Yuan N; Ma J; Zheng Q; Liu F FASEB J 2021[Apr]; 35 (4): e21384 PMID33710662show ga Novel coronary pneumonia (COVID-19) is a respiratory distress syndrome caused by a new type of coronavirus. Understanding the genetic basis of susceptibility and prognosis to COVID-19 is of great significance to disease prevention, molecular typing, prognosis, and treatment. However, so far, there have been only two genome-wide association studies (GWASs) on the susceptibility of COVID-19. Starting with these reported DNA variants, we found the genes regulated by these variants through cis-eQTL and cis-meQTL acting. We further did a series of bioinformatics analysis on these potential risk genes. The analysis shows that the genetic variants on EHF regulate the expression of its neighbor CAT gene via cis-eQTL. There was significant evidence that CAT and the SARS-CoV-2-related S protein binding protein ACE2 interact with each other. Intracellular localization results showed that CAT and ACE2 proteins both exists in the cell membrane and extracellular area and their interaction could have an impact on the cell invasion ability of S protein. In addition, the expression of these three genes showed a significant positive correlation in the lungs. Based on these results, we propose that CAT plays a crucial intermediary role in binding effectiveness of ACE2, thereby affecting the susceptibility to COVID-19. |*COVID-19/genetics/metabolism[MESH] |*Catalase/biosynthesis/genetics[MESH] |*Gene Expression Regulation, Enzymologic[MESH] |*Genetic Predisposition to Disease[MESH] |*Polymorphism, Genetic[MESH] |Angiotensin-Converting Enzyme 2/genetics/metabolism[MESH] |Female[MESH] |Genome-Wide Association Study[MESH] |Humans[MESH] |Male[MESH] |Retrospective Studies[MESH] |SARS-CoV-2/*metabolism[MESH] |Spike Glycoprotein, Coronavirus/genetics/metabolism[MESH]Evidence for CAT gene being functionally involved in the susceptibilit(epmc).pdf DeepDyve Pubget Overpricing