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10.1002/jmv.26937

http://scihub22266oqcxt.onion/10.1002/jmv.26937
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33710634!8250967!33710634
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suck abstract from ncbi


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pmid33710634      J+Med+Virol 2021 ; 93 (7): 4242-4246
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  • Potential false-positive reasons for SARS-CoV-2 antibody testing and its solution #MMPMID33710634
  • Ye Q; Zhang T; Lu D
  • J Med Virol 2021[Jul]; 93 (7): 4242-4246 PMID33710634show ga
  • Coronavirus disease 2019 (COVID-19) has brought a huge impact on global health and the economy. Early diagnosis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is essential for epidemic prevention and control. The detection of SARS-CoV-2 antibodies is an important criterion for diagnosing COVID-19. However, SARS-CoV-2 antibody testing also has certain false positives causing confusion in clinical diagnosis. This article summarizes the causes of false-positive detection of SARS-CoV-2 antibodies in clinical practice. The results indicate that the most common endogenous interferences include rheumatoid factor, heterophile antibodies, human anti-animal antibodies, lysozyme, complement, and cross-antigens. The exogenous interference is mainly incomplete coagulation of the specimen, contamination of the specimen, and insufficient optimization of the diagnostic kit's reaction system.
  • |Antibodies, Viral/*blood[MESH]
  • |COVID-19 Testing/*methods[MESH]
  • |COVID-19/*diagnosis[MESH]
  • |Clinical Laboratory Techniques/methods[MESH]
  • |False Positive Reactions[MESH]
  • |Humans[MESH]
  • |Immunologic Tests/methods[MESH]


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