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10.1002/anie.202100543 http://scihub22266oqcxt.onion/10.1002/anie.202100543 33709491!8251112!33709491     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Angew+Chem+Int+Ed+Engl 2021 ; 60 (23): 12904-12910 Nephropedia Template TP {{tp|p=33709491|t=2021. Synthetic Homogeneous Glycoforms of the SARS-CoV-2 Spike Receptor-Binding Domain Reveals Different Binding Profiles of Monoclonal Antibodies |pdf=|usr=}}{{33709491}} gab.com Text Synthetic Homogeneous Glycoforms of the SARS-CoV-2 Spike Receptor-Binding Domain Reveals Different Binding Profiles of Monoclonal Antibodies JO: Angew Chem Int Ed Engl http://www.kidney.de/pget.php?&tw=1&pmid=33709491 #FOAvip SARS-CoV-2 attaches to its host receptor, angiotensin-converting enzyme 2 (ACE2), via the receptor-binding domain (RBD) of the spike protein. The RBD glycoprotein is a critical target for the development of neutralizing antibodies and vaccines against SARS-CoV-2. However, the high heterogeneity of RBD glycoforms may lead to an incomplete neutralization effect and impact the immunogenic integrity of RBD-based vaccines. Investigating the role of different carbohydrate domains is of paramount importance. Unfortunately, there is no viable method for preparing RBD glycoproteins with structurally defined glycans. Herein we describe a highly efficient and scalable strategy for the preparation of six glycosylated RBDs bearing defined structure glycoforms at T323, N331, and N343. A combination of modern oligosaccharide, peptide synthesis and recombinant protein engineering provides a robust route to decipher carbohydrate structure-function relationships. Twit Text FOAVip Synthetic Homogeneous Glycoforms of the SARS-CoV-2 Spike Receptor-Binding Domain Reveals Different Binding Profiles of Monoclonal Antibodies ????Angew Chem Int Ed Engl http://www.kidney.de/pget.php?&tw=1&pmid=33709491 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33709491 #FOAvip English Wikipedia <ref>{{Cite pmid|33709491}}</ref> Synthetic Homogeneous Glycoforms of the SARS-CoV-2 Spike Receptor-Binding Domain Reveals Different Binding Profiles of Monoclonal Antibodies #MMPMID33709491 Ye F; Zhao J; Xu P; Liu X; Yu J; Shangguan W; Liu J; Luo X; Li C; Ying T; Wang J; Yu B; Wang P Angew Chem Int Ed Engl 2021[Jun]; 60 (23): 12904-12910 PMID33709491show ga SARS-CoV-2 attaches to its host receptor, angiotensin-converting enzyme 2 (ACE2), via the receptor-binding domain (RBD) of the spike protein. The RBD glycoprotein is a critical target for the development of neutralizing antibodies and vaccines against SARS-CoV-2. However, the high heterogeneity of RBD glycoforms may lead to an incomplete neutralization effect and impact the immunogenic integrity of RBD-based vaccines. Investigating the role of different carbohydrate domains is of paramount importance. Unfortunately, there is no viable method for preparing RBD glycoproteins with structurally defined glycans. Herein we describe a highly efficient and scalable strategy for the preparation of six glycosylated RBDs bearing defined structure glycoforms at T323, N331, and N343. A combination of modern oligosaccharide, peptide synthesis and recombinant protein engineering provides a robust route to decipher carbohydrate structure-function relationships. |Amino Acid Sequence[MESH] |Angiotensin-Converting Enzyme 2/chemistry/metabolism[MESH] |Antibodies, Monoclonal/*immunology[MESH] |Antigen-Antibody Reactions[MESH] |Binding Sites[MESH] |COVID-19/pathology/virology[MESH] |Glycosylation[MESH] |Humans[MESH] |Kinetics[MESH] |Peptide Library[MESH] |Peptides/chemical synthesis/immunology/metabolism[MESH] |Protein Binding[MESH] |Protein Engineering[MESH] |Protein Folding[MESH] |Protein Structure, Tertiary[MESH] |SARS-CoV-2/isolation & purification/*metabolism[MESH] |Spike Glycoprotein, Coronavirus/chemistry/genetics/*immunology/metabolism[MESH]Synthetic Homogeneous Glycoforms of the SARS-CoV-2 Spike Receptor-Bind(epmc).pdf DeepDyve Pubget Overpricing