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10.1038/s41467-021-21767-3

http://scihub22266oqcxt.onion/10.1038/s41467-021-21767-3
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33707453!7952905!33707453
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suck abstract from ncbi


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pmid33707453      Nat+Commun 2021 ; 12 (1): 1607
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  • Bat and pangolin coronavirus spike glycoprotein structures provide insights into SARS-CoV-2 evolution #MMPMID33707453
  • Zhang S; Qiao S; Yu J; Zeng J; Shan S; Tian L; Lan J; Zhang L; Wang X
  • Nat Commun 2021[Mar]; 12 (1): 1607 PMID33707453show ga
  • In recognizing the host cellular receptor and mediating fusion of virus and cell membranes, the spike (S) glycoprotein of coronaviruses is the most critical viral protein for cross-species transmission and infection. Here we determined the cryo-EM structures of the spikes from bat (RaTG13) and pangolin (PCoV_GX) coronaviruses, which are closely related to SARS-CoV-2. All three receptor-binding domains (RBDs) of these two spike trimers are in the "down" conformation, indicating they are more prone to adopt the receptor-binding inactive state. However, we found that the PCoV_GX, but not the RaTG13, spike is comparable to the SARS-CoV-2 spike in binding the human ACE2 receptor and supporting pseudovirus cell entry. We further identified critical residues in the RBD underlying different activities of the RaTG13 and PCoV_GX/SARS-CoV-2 spikes. These results collectively indicate that tight RBD-ACE2 binding and efficient RBD conformational sampling are required for the evolution of SARS-CoV-2 to gain highly efficient infection.
  • |Amino Acid Sequence[MESH]
  • |Angiotensin-Converting Enzyme 2/chemistry[MESH]
  • |Animals[MESH]
  • |COVID-19/epidemiology/transmission/*virology[MESH]
  • |Chiroptera/*virology[MESH]
  • |Coronavirus/*chemistry/*genetics[MESH]
  • |Cryoelectron Microscopy[MESH]
  • |Evolution, Molecular[MESH]
  • |Host Microbial Interactions[MESH]
  • |Humans[MESH]
  • |Models, Molecular[MESH]
  • |Pandemics[MESH]
  • |Pangolins/*virology[MESH]
  • |Protein Domains[MESH]
  • |SARS-CoV-2/*chemistry/*genetics[MESH]
  • |Sequence Homology, Amino Acid[MESH]
  • |Species Specificity[MESH]


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