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10.1038/s41419-021-03540-y http://scihub22266oqcxt.onion/10.1038/s41419-021-03540-y 33707411!7948172!33707411     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\33707411.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cell+Death+Dis 2021 ; 12 (3): 258 Nephropedia Template TP {{tp|p=33707411|t=2021. Metabolomic analyses of COVID-19 patients unravel stage-dependent and prognostic biomarkers |pdf=|usr=}}{{33707411}} gab.com Text Metabolomic analyses of COVID-19 patients unravel stage-dependent and prognostic biomarkers JO: Cell Death Dis http://www.kidney.de/pget.php?&tw=1&pmid=33707411 #FOAvip The circulating metabolome provides a snapshot of the physiological state of the organism responding to pathogenic challenges. Here we report alterations in the plasma metabolome reflecting the clinical presentation of COVID-19 patients with mild (ambulatory) diseases, moderate disease (radiologically confirmed pneumonitis, hospitalization and oxygen therapy), and critical disease (in intensive care). This analysis revealed major disease- and stage-associated shifts in the metabolome, meaning that at least 77 metabolites including amino acids, lipids, polyamines and sugars, as well as their derivatives, were altered in critical COVID-19 patient's plasma as compared to mild COVID-19 patients. Among a uniformly moderate cohort of patients who received tocilizumab, only 10 metabolites were different among individuals with a favorable evolution as compared to those who required transfer into the intensive care unit. The elevation of one single metabolite, anthranilic acid, had a poor prognostic value, correlating with the maintenance of high interleukin-10 and -18 levels. Given that products of the kynurenine pathway including anthranilic acid have immunosuppressive properties, we speculate on the therapeutic utility to inhibit the rate-limiting enzymes of this pathway including indoleamine 2,3-dioxygenase and tryptophan 2,3-dioxygenase. Twit Text FOAVip Metabolomic analyses of COVID-19 patients unravel stage-dependent and prognostic biomarkers ????Cell Death Dis http://www.kidney.de/pget.php?&tw=1&pmid=33707411 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33707411 #FOAvip English Wikipedia <ref>{{Cite pmid|33707411}}</ref> Metabolomic analyses of COVID-19 patients unravel stage-dependent and prognostic biomarkers #MMPMID33707411 Danlos FX; Grajeda-Iglesias C; Durand S; Sauvat A; Roumier M; Cantin D; Colomba E; Rohmer J; Pommeret F; Baciarello G; Willekens C; Vasse M; Griscelli F; Fahrner JE; Goubet AG; Dubuisson A; Derosa L; Nirmalathasan N; Bredel D; Mouraud S; Pradon C; Stoclin A; Rozenberg F; Duchemin J; Jourdi G; Ellouze S; Levavasseur F; Albiges L; Soria JC; Barlesi F; Solary E; Andre F; Pene F; Ackerman F; Mouthon L; Zitvogel L; Marabelle A; Michot JM; Fontenay M; Kroemer G Cell Death Dis 2021[Mar]; 12 (3): 258 PMID33707411show ga The circulating metabolome provides a snapshot of the physiological state of the organism responding to pathogenic challenges. Here we report alterations in the plasma metabolome reflecting the clinical presentation of COVID-19 patients with mild (ambulatory) diseases, moderate disease (radiologically confirmed pneumonitis, hospitalization and oxygen therapy), and critical disease (in intensive care). This analysis revealed major disease- and stage-associated shifts in the metabolome, meaning that at least 77 metabolites including amino acids, lipids, polyamines and sugars, as well as their derivatives, were altered in critical COVID-19 patient's plasma as compared to mild COVID-19 patients. Among a uniformly moderate cohort of patients who received tocilizumab, only 10 metabolites were different among individuals with a favorable evolution as compared to those who required transfer into the intensive care unit. The elevation of one single metabolite, anthranilic acid, had a poor prognostic value, correlating with the maintenance of high interleukin-10 and -18 levels. Given that products of the kynurenine pathway including anthranilic acid have immunosuppressive properties, we speculate on the therapeutic utility to inhibit the rate-limiting enzymes of this pathway including indoleamine 2,3-dioxygenase and tryptophan 2,3-dioxygenase. |*Metabolome[MESH] |Antibodies, Monoclonal, Humanized/administration & dosage[MESH] |Biomarkers/blood[MESH] |COVID-19 Drug Treatment[MESH] |COVID-19/*blood/diagnosis[MESH] |Female[MESH] |Humans[MESH] |Male[MESH] |Metabolomics[MESH] |Prognosis[MESH]Metabolomic analyses of COVID-19 patients unravel stage-dependent and (epmc).pdf DeepDyve Pubget Overpricing