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10.3904/kjim.2020.633

http://scihub22266oqcxt.onion/10.3904/kjim.2020.633
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33706472!9082427!33706472
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suck abstract from ncbi


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pmid33706472      Korean+J+Intern+Med 2022 ; 37 (3): 673-680
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  • Baseline use of hydroxychloroquine or immunosuppressive drugs and the risk of coronavirus disease 2019 #MMPMID33706472
  • Kim JW; Kwak SG; Lee H; Kim SK; Choe JY; Park SH
  • Korean J Intern Med 2022[May]; 37 (3): 673-680 PMID33706472show ga
  • BACKGROUND/AIMS: The preventive role of hydroxychloroquine (HCQ) on coronavirus disease 2019 (COVID-19) remains unclear. The aim of this study was to examine the effects of HCQ and other immunosuppressive drugs on the incidence of COVID-19. METHODS: The data were collected from the South Korea National Health Insurance Sharing-COVID-19 database. All individuals who underwent nasopharyngeal and oropharyngeal swab tests for COVID-19 from January 2020 to May 2020 are included. The association between COVID-19 risk and HCQ use was examined in a propensity score-matched population. Factors associated with COVID-19 were identified using multiple logistic regression analysis. RESULTS: Total 8,070 patients with COVID-19 and 121,050 negative controls were included from the database. Among all participants, 381 were HCQ users. In a propensity score-matched population, the incidence of COVID-19 was 7.1% in HCQ users and 6.8% in non-users. The odds ratio (OR) for HCQ use was 1.05 with a 95% confidence interval (CI) of 0.58 to 1.89. Among the subpopulation of patients with rheumatoid arthritis (RA), 33 were diagnosed with COVID-19 and 478 were not. Use of HCQ, glucocorticoids, or other immunosuppressive drugs was not associated with COVID-19 risk, whereas abatacept use was. Chronic lung disease was an independent risk factor for COVID-19 diagnosis in patients with RA (adjusted OR, 6.07; 95% CI, 1.10 to 33.59). CONCLUSION: The risk of COVID-19 did not differ between HCQ users and non-users. Glucocorticoids, conventional disease-modifying antirheumatic drugs (DMARDs), and biological DMARDs other than abatacept did not increase the risk of COVID-19.
  • |*Antirheumatic Agents/adverse effects[MESH]
  • |*Arthritis, Rheumatoid/drug therapy[MESH]
  • |*COVID-19 Drug Treatment[MESH]
  • |*COVID-19/epidemiology[MESH]
  • |Abatacept/therapeutic use[MESH]
  • |COVID-19 Testing[MESH]
  • |Glucocorticoids/therapeutic use[MESH]
  • |Humans[MESH]
  • |Hydroxychloroquine/adverse effects[MESH]


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