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Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Virology 2021 ; 558 (ä): 13-21 Nephropedia Template TP
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Characterization of neutralizing versus binding antibodies and memory B cells in COVID-19 recovered individuals from India #MMPMID33706207
Nayak K; Gottimukkala K; Kumar S; Reddy ES; Edara VV; Kauffman R; Floyd K; Mantus G; Savargaonkar D; Goel PK; Arora S; Rahi M; Davis CW; Linderman S; Wrammert J; Suthar MS; Ahmed R; Sharma A; Murali-Krishna K; Chandele A
Virology 2021[Jun]; 558 (ä): 13-21 PMID33706207show ga
India is one of the most affected countries by COVID-19 pandemic; but little is understood regarding immune responses to SARS-CoV-2 in this region. Herein we examined SARS-CoV-2 neutralizing antibodies, IgG, IgM, IgA and memory B cells in COVID-19 recovered individual from India. While a vast majority of COVID-19 recovered individuals showed SARS-CoV-2 RBD-specific IgG, IgA and IgM antibodies (38/42, 90.47%; 21/42, 50%; 33/42, 78.57% respectively), only half of them had appreciable neutralizing antibody titers. RBD-specific IgG, but not IgA or IgM titers, correlated with neutralizing antibody titers and RBD-specific memory B cell frequencies. These findings have timely significance for identifying potential donors for plasma therapy using RBD-specific IgG assays as surrogate measurement for neutralizing antibodies in India. Further, this study provides useful information needed for designing large-scale studies towards understanding of inter-individual variation in immune memory to SARS CoV-2 natural infection for future vaccine evaluation and implementation efforts.