Methotrexate works remotely, from the gut #MMPMID33705703
Wu HJ
Cell Host Microbe 2021[Mar]; 29 (3): 325-326 PMID33705703show ga
In this COVID era, when many struggle to work remotely, methotrexate (MTX) has been doing so all along. In this issue of Cell Host & Microbe, Nayak et al. discover that MTX reduces immune activation due to off-target effects on the gut microbiota, potentially explaining MTX's anti-inflammatory effects.