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Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 J+Mol+Cell+Biol 2021 ; 13 (3): 175-184 Nephropedia Template TP
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What makes (hydroxy)chloroquine ineffective against COVID-19: insights from cell biology #MMPMID33693723
Altulea D; Maassen S; Baranov MV; van den Bogaart G
J Mol Cell Biol 2021[Jul]; 13 (3): 175-184 PMID33693723show ga
Since chloroquine (CQ) and hydroxychloroquine (HCQ) can inhibit the invasion and proliferation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in cultured cells, the repurposing of these antimalarial drugs was considered a promising strategy for treatment and prevention of coronavirus disease (COVID-19). However, despite promising preliminary findings, many clinical trials showed neither significant therapeutic nor prophylactic benefits of CQ and HCQ against COVID-19. Here, we aim to answer the question of why these drugs are not effective against the disease by examining the cellular working mechanisms of CQ and HCQ in prevention of SARS-CoV-2 infections.