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10.3389/fmolb.2021.632290 http://scihub22266oqcxt.onion/10.3389/fmolb.2021.632290 33693030!7937875!33693030     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Mol+Biosci 2021 ; 8 (ä): 632290 Nephropedia Template TP {{tp|p=33693030|t=2021. Circulating Exosomes Are Strongly Involved in SARS-CoV-2 Infection |pdf=|usr=}}{{33693030}} gab.com Text Circulating Exosomes Are Strongly Involved in SARS-CoV-2 Infection JO: Front Mol Biosci http://www.kidney.de/pget.php?&tw=1&pmid=33693030 #FOAvip Knowledge of the host response to the novel coronavirus SARS-CoV-2 remains limited, hindering the understanding of COVID-19 pathogenesis and the development of therapeutic strategies. During the course of a viral infection, host cells release exosomes and other extracellular vesicles carrying viral and host components that can modulate the immune response. The present study used a shotgun proteomic approach to map the host circulating exosomes' response to SARS-CoV-2 infection. We investigated how SARS-CoV-2 infection modulates exosome content, exosomes' involvement in disease progression, and the potential use of plasma exosomes as biomarkers of disease severity. A proteomic analysis of patient-derived exosomes identified several molecules involved in the immune response, inflammation, and activation of the coagulation and complement pathways, which are the main mechanisms of COVID-19-associated tissue damage and multiple organ dysfunctions. In addition, several potential biomarkers-such as fibrinogen, fibronectin, complement C1r subcomponent and serum amyloid P-component-were shown to have a diagnostic feature presenting an area under the curve (AUC) of almost 1. Proteins correlating with disease severity were also detected. Moreover, for the first time, we identified the presence of SARS-CoV-2 RNA in the exosomal cargo, which suggests that the virus might use the endocytosis route to spread infection. Our findings indicate circulating exosomes' significant contribution to several processes-such as inflammation, coagulation, and immunomodulation-during SARS-CoV-2 infection. The study's data are available via ProteomeXchange with the identifier PXD021144. Twit Text FOAVip Circulating Exosomes Are Strongly Involved in SARS-CoV-2 Infection ????Front Mol Biosci http://www.kidney.de/pget.php?&tw=1&pmid=33693030 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33693030 #FOAvip English Wikipedia <ref>{{Cite pmid|33693030}}</ref> Circulating Exosomes Are Strongly Involved in SARS-CoV-2 Infection #MMPMID33693030 Barberis E; Vanella VV; Falasca M; Caneapero V; Cappellano G; Raineri D; Ghirimoldi M; De Giorgis V; Puricelli C; Vaschetto R; Sainaghi PP; Bruno S; Sica A; Dianzani U; Rolla R; Chiocchetti A; Cantaluppi V; Baldanzi G; Marengo E; Manfredi M Front Mol Biosci 2021[]; 8 (ä): 632290 PMID33693030show ga Knowledge of the host response to the novel coronavirus SARS-CoV-2 remains limited, hindering the understanding of COVID-19 pathogenesis and the development of therapeutic strategies. During the course of a viral infection, host cells release exosomes and other extracellular vesicles carrying viral and host components that can modulate the immune response. The present study used a shotgun proteomic approach to map the host circulating exosomes' response to SARS-CoV-2 infection. We investigated how SARS-CoV-2 infection modulates exosome content, exosomes' involvement in disease progression, and the potential use of plasma exosomes as biomarkers of disease severity. A proteomic analysis of patient-derived exosomes identified several molecules involved in the immune response, inflammation, and activation of the coagulation and complement pathways, which are the main mechanisms of COVID-19-associated tissue damage and multiple organ dysfunctions. In addition, several potential biomarkers-such as fibrinogen, fibronectin, complement C1r subcomponent and serum amyloid P-component-were shown to have a diagnostic feature presenting an area under the curve (AUC) of almost 1. Proteins correlating with disease severity were also detected. Moreover, for the first time, we identified the presence of SARS-CoV-2 RNA in the exosomal cargo, which suggests that the virus might use the endocytosis route to spread infection. Our findings indicate circulating exosomes' significant contribution to several processes-such as inflammation, coagulation, and immunomodulation-during SARS-CoV-2 infection. The study's data are available via ProteomeXchange with the identifier PXD021144. äCirculating Exosomes Are Strongly Involved in SARS-CoV-2 Infection (epmc).pdf DeepDyve Pubget Overpricing