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10.1038/s41598-021-84913-3 http://scihub22266oqcxt.onion/10.1038/s41598-021-84913-3 33692390!7946906!33692390     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2021 ; 11 (1): 5538 Nephropedia Template TP {{tp|p=33692390|t=2021. Antibody isotype diversity against SARS-CoV-2 is associated with differential serum neutralization capacities |pdf=|usr=}}{{33692390}} gab.com Text Antibody isotype diversity against SARS-CoV-2 is associated with differential serum neutralization capacities JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=33692390 #FOAvip Understanding antibody responses to SARS-CoV-2 is indispensable for the development of containment measures to overcome the current COVID-19 pandemic. Recent studies showed that serum from convalescent patients can display variable neutralization capacities. Still, it remains unclear whether there are specific signatures that can be used to predict neutralization. Here, we performed a detailed analysis of sera from a cohort of 101 recovered healthcare workers and we addressed their SARS-CoV-2 antibody response by ELISA against SARS-CoV-2 Spike receptor binding domain and nucleoprotein. Both ELISA methods detected sustained levels of serum IgG against both antigens. Yet, the majority of individuals from our cohort generated antibodies with low neutralization capacity and only 6% showed high neutralizing titers against both authentic SARS-CoV-2 virus and the Spike pseudotyped virus. Interestingly, higher neutralizing sera correlate with detection of -IgG, IgM and IgA antibodies against both antigens, while individuals with positive IgG alone showed poor neutralization response. These results suggest that having a broader repertoire of antibodies may contribute to more potent SARS-CoV-2 neutralization. Altogether, our work provides a cross sectional snapshot of the SARS-CoV-2 neutralizing antibody response in recovered healthcare workers and provides preliminary evidence that possessing multiple antibody isotypes can play an important role in predicting SARS-CoV-2 neutralization. Twit Text FOAVip Antibody isotype diversity against SARS-CoV-2 is associated with differential serum neutralization capacities ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=33692390 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33692390 #FOAvip English Wikipedia <ref>{{Cite pmid|33692390}}</ref> Antibody isotype diversity against SARS-CoV-2 is associated with differential serum neutralization capacities #MMPMID33692390 Noval MG; Kaczmarek ME; Koide A; Rodriguez-Rodriguez BA; Louie P; Tada T; Hattori T; Panchenko T; Romero LA; Teng KW; Bazley A; de Vries M; Samanovic MI; Weiser JN; Aifantis I; Cangiarella J; Mulligan MJ; Desvignes L; Dittmann M; Landau NR; Aguero-Rosenfeld M; Koide S; Stapleford KA Sci Rep 2021[Mar]; 11 (1): 5538 PMID33692390show ga Understanding antibody responses to SARS-CoV-2 is indispensable for the development of containment measures to overcome the current COVID-19 pandemic. Recent studies showed that serum from convalescent patients can display variable neutralization capacities. Still, it remains unclear whether there are specific signatures that can be used to predict neutralization. Here, we performed a detailed analysis of sera from a cohort of 101 recovered healthcare workers and we addressed their SARS-CoV-2 antibody response by ELISA against SARS-CoV-2 Spike receptor binding domain and nucleoprotein. Both ELISA methods detected sustained levels of serum IgG against both antigens. Yet, the majority of individuals from our cohort generated antibodies with low neutralization capacity and only 6% showed high neutralizing titers against both authentic SARS-CoV-2 virus and the Spike pseudotyped virus. Interestingly, higher neutralizing sera correlate with detection of -IgG, IgM and IgA antibodies against both antigens, while individuals with positive IgG alone showed poor neutralization response. These results suggest that having a broader repertoire of antibodies may contribute to more potent SARS-CoV-2 neutralization. Altogether, our work provides a cross sectional snapshot of the SARS-CoV-2 neutralizing antibody response in recovered healthcare workers and provides preliminary evidence that possessing multiple antibody isotypes can play an important role in predicting SARS-CoV-2 neutralization. |Adult[MESH] |Antibodies, Neutralizing/*immunology[MESH] |Antibodies, Viral/immunology[MESH] |COVID-19/*immunology/therapy[MESH] |Cohort Studies[MESH] |Cross-Sectional Studies[MESH] |Enzyme-Linked Immunosorbent Assay/methods[MESH] |Epitopes/immunology[MESH] |Female[MESH] |Humans[MESH] |Immunoglobulin A/blood[MESH] |Immunoglobulin G/blood[MESH] |Male[MESH] |Neutralization Tests/methods[MESH] |Pandemics[MESH] |SARS-CoV-2/*immunology/pathogenicity[MESH] |Serum/immunology[MESH]Antibody isotype diversity against SARS-CoV-2 is associated with diffe(epmc).pdf DeepDyve Pubget Overpricing