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10.1038/s41598-021-84840-3

http://scihub22266oqcxt.onion/10.1038/s41598-021-84840-3
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33692386!7946952!33692386
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suck abstract from ncbi


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pmid33692386      Sci+Rep 2021 ; 11 (1): 5558
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  • Blockade of SARS-CoV-2 spike protein-mediated cell-cell fusion using COVID-19 convalescent plasma #MMPMID33692386
  • Wang L; Zhao J; Nguyen LNT; Adkins JL; Schank M; Khanal S; Nguyen LN; Dang X; Cao D; Thakuri BKC; Lu Z; Zhang J; Zhang Y; Wu XY; El Gazzar M; Ning S; Moorman JP; Yao ZQ
  • Sci Rep 2021[Mar]; 11 (1): 5558 PMID33692386show ga
  • The recent COVID-19 pandemic poses a serious threat to global public health, thus there is an urgent need to define the molecular mechanisms involved in SARS-CoV-2 spike (S) protein-mediated virus entry that is essential for preventing and/or treating this emerging infectious disease. In this study, we examined the blocking activity of human COVID-19 convalescent plasma by cell-cell fusion assays using SARS-CoV-2-S-transfected 293 T as effector cells and ACE2-expressing 293 T as target cells. We demonstrate that the SARS-CoV-2 S protein exhibits a very high capacity for membrane fusion and is efficient in mediating virus fusion and entry into target cells. Importantly, we find that COVID-19 convalescent plasma with high titers of IgG neutralizing antibodies can block cell-cell fusion and virus entry by interfering with the SARS-CoV-2-S/ACE2 or SARS-CoV-S/ACE2 interactions. These findings suggest that COVID-19 convalescent plasma may not only inhibit SARS-CoV-2-S but also cross-neutralize SARS-CoV-S-mediated membrane fusion and virus entry, supporting its potential as a preventive and/or therapeutic agent against SARS-CoV-2 as well as other SARS-CoV infections.
  • |Adult[MESH]
  • |Antibodies, Neutralizing/immunology[MESH]
  • |Antibodies, Viral/immunology[MESH]
  • |COVID-19 Serotherapy[MESH]
  • |COVID-19/*immunology/prevention & control/*therapy[MESH]
  • |Cell Fusion/methods[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Immunization, Passive/methods[MESH]
  • |Male[MESH]
  • |Membrane Fusion/drug effects[MESH]
  • |Middle Aged[MESH]
  • |Pandemics/prevention & control[MESH]
  • |Plasma/chemistry[MESH]
  • |Receptors, Virus/metabolism[MESH]
  • |SARS-CoV-2/immunology/pathogenicity[MESH]
  • |Spike Glycoprotein, Coronavirus/*immunology/metabolism[MESH]


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