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10.1272/jnms.JNMS.2022_89-104

http://scihub22266oqcxt.onion/10.1272/jnms.JNMS.2022_89-104
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33692301!ä!33692301

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suck abstract from ncbi


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pmid33692301      J+Nippon+Med+Sch 2021 ; 88 (6): 533-539
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  • Physical Compatibility of Nafamostat with Analgesics, Sedatives, and Muscle Relaxants for Treatment of Coronavirus Disease 2019 #MMPMID33692301
  • Kondo M; Nagano M; Yoshida M; Yoshida N; Tagui N; Yoshida M; Sugaya K; Takase H
  • J Nippon Med Sch 2021[Dec]; 88 (6): 533-539 PMID33692301show ga
  • BACKGROUND: Severe coronavirus disease 2019 (COVID-19) may require continuous administration of analgesics, sedatives, and muscle relaxants. Nafamostat has recently been reported as a therapeutic agent for COVID-19. However, there is a lack of information on the compatibility of nafamostat with the aforementioned drug classes. This study evaluated the physical compatibility of nafamostat with these drug classes. METHODS: Nafamostat was combined with 1-3 target drugs (fentanyl, morphine, midazolam, dexmedetomidine, and rocuronium). Fifteen physical compatibility tests were conducted. Nafamostat was dissolved in 5% glucose solution; the final concentration was 10 mg/mL. All other medications were diluted in 0.9% sodium chloride to obtain clinically relevant concentrations. The power of hydrogen (pH) of all medications was measured during each test. Compatibility tests were conducted with 4 test solutions in which nafamostat and the target drugs were compounded at equal volume ratios (1:1, 1:1:1, or 1:1:1:1). Visual appearance, turbidity, and pH were evaluated immediately after mixing and at 1 and 3 hours. Physical incompatibilities were defined as gross precipitation, cloudiness, appearance of the Tyndall effect, or a turbidity change of >/=0.5 nephelometric turbidity units (NTU) based on nafamostat. RESULTS: The mean pH of nafamostat was 3.13 +/- 0.03. The combination of nafamostat, fentanyl, and dexmedetomidine had the highest pH (3.39 +/- 0.01; 3 hours after mixing). All drugs were compatible with nafamostat until 3 hours after admixture, with a mean turbidity value of
  • |*COVID-19 Drug Treatment[MESH]
  • |*Drug Incompatibility[MESH]
  • |Analgesics/*therapeutic use[MESH]
  • |Benzamidines/*therapeutic use[MESH]
  • |Dexmedetomidine/therapeutic use[MESH]
  • |Fentanyl/*therapeutic use[MESH]
  • |Guanidines/*therapeutic use[MESH]
  • |Humans[MESH]
  • |Hypnotics and Sedatives[MESH]
  • |Muscle Relaxants, Central/*therapeutic use[MESH]
  • |SARS-CoV-2[MESH]


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