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10.1272/jnms.JNMS.2022_89-102

http://scihub22266oqcxt.onion/10.1272/jnms.JNMS.2022_89-102
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33692300!ä!33692300

suck abstract from ncbi


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pmid33692300      J+Nippon+Med+Sch 2021 ; 88 (6): 524-532
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  • Effectiveness of the 2019-2020 Influenza Vaccine and the Effect of Prior Influenza Infection and Vaccination in Children during the First Influenza Season Overlapping with the COVID-19 Epidemic #MMPMID33692300
  • Ando S
  • J Nippon Med Sch 2021[Dec]; 88 (6): 524-532 PMID33692300show ga
  • BACKGROUND: Behavioral changes among Japanese, along with the coronavirus disease 2019 (COVID-19) epidemic, may affect the seasonal influenza epidemic in Japan and change influenza vaccine effectiveness (VE). METHODS: This single-center, test-negative case-control (TNCC) study estimated influenza VE in children for the first influenza season (2019/20) to overlap the COVID-19 epidemic in. Effects of prior influenza infection and vaccination in children were assessed for the 2019-2020 season. RESULTS: Among 386 children, adjusted VE was significant for influenza A/H1N1 (45.5%; 95% confidence interval [CI]: 2.0-69.7) and influenza B (66.7%; 95% CI: 35.9-82.7). Among patients aged 0-6 years, adjusted VE was significant for influenza A (total: A/H1N1+A/H3N2) (65.0%; 95% CI: 22.2-84.3), influenza A/H1N1 (64.8%; 95% CI: 16.9-85.1) and influenza B (87.4%; 95% CI: 50.5-96.8). No VE was observed in patients aged 7-15 years. Administration of two vaccine doses tended to decrease incidences of influenza A (total) and influenza A/H1N1 in patients aged 0-6 years. The adjusted odds ratios (ORs) of influenza B infection in patients, who had influenza during the previous season, were significantly lower among all participants (0.29; 95% CI: 0.11-0.78) and patients aged 7-15 years (0.34; 95% CI: 0.12-0.94). The adjusted ORs of influenza infections were not significant in patients vaccinated during the previous season. CONCLUSIONS: TNCC-based estimates of influenza VE were consistent despite the overlapping COVID-19 epidemic.
  • |*COVID-19/epidemiology[MESH]
  • |*Vaccine Efficacy[MESH]
  • |Case-Control Studies[MESH]
  • |Child[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Infant[MESH]
  • |Influenza A Virus, H1N1 Subtype/immunology[MESH]
  • |Influenza A Virus, H3N2 Subtype/immunology[MESH]
  • |Influenza Vaccines/*administration & dosage/adverse effects[MESH]
  • |Influenza, Human/epidemiology/*prevention & control[MESH]
  • |Male[MESH]
  • |SARS-CoV-2[MESH]
  • |Seasons[MESH]


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