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Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Emerg+Microbes+Infect 2021 ; 10 (1): 629-637 Nephropedia Template TP
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Heterologous prime-boost: breaking the protective immune response bottleneck of COVID-19 vaccine candidates #MMPMID33691606
He Q; Mao Q; An C; Zhang J; Gao F; Bian L; Li C; Liang Z; Xu M; Wang J
Emerg Microbes Infect 2021[Dec]; 10 (1): 629-637 PMID33691606show ga
COVID-19 vaccines emerging from different platforms differ in efficacy, duration of protection, and side effects. To maximize the benefits of vaccination, we explored the utility of employing a heterologous prime-boost strategy in which different combinations of the four types of leading COVID-19 vaccine candidates that are undergoing clinical trials in China were tested in a mouse model. Our results showed that sequential immunization with adenovirus vectored vaccine followed by inactivated/recombinant subunit/mRNA vaccine administration specifically increased levels of neutralizing antibodies and promoted the modulation of antibody responses to predominantly neutralizing antibodies. Moreover, a heterologous prime-boost regimen with an adenovirus vector vaccine also improved Th1-biased T cell responses. Our results provide new ideas for the development and application of COVID-19 vaccines to control the SARS-CoV-2 pandemic.