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10.1080/22221751.2021.1902245

http://scihub22266oqcxt.onion/10.1080/22221751.2021.1902245
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33691606!8009122!33691606
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suck abstract from ncbi


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pmid33691606      Emerg+Microbes+Infect 2021 ; 10 (1): 629-637
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  • Heterologous prime-boost: breaking the protective immune response bottleneck of COVID-19 vaccine candidates #MMPMID33691606
  • He Q; Mao Q; An C; Zhang J; Gao F; Bian L; Li C; Liang Z; Xu M; Wang J
  • Emerg Microbes Infect 2021[Dec]; 10 (1): 629-637 PMID33691606show ga
  • COVID-19 vaccines emerging from different platforms differ in efficacy, duration of protection, and side effects. To maximize the benefits of vaccination, we explored the utility of employing a heterologous prime-boost strategy in which different combinations of the four types of leading COVID-19 vaccine candidates that are undergoing clinical trials in China were tested in a mouse model. Our results showed that sequential immunization with adenovirus vectored vaccine followed by inactivated/recombinant subunit/mRNA vaccine administration specifically increased levels of neutralizing antibodies and promoted the modulation of antibody responses to predominantly neutralizing antibodies. Moreover, a heterologous prime-boost regimen with an adenovirus vector vaccine also improved Th1-biased T cell responses. Our results provide new ideas for the development and application of COVID-19 vaccines to control the SARS-CoV-2 pandemic.
  • |Adenovirus Vaccines/administration & dosage/*immunology[MESH]
  • |Animals[MESH]
  • |Antibodies, Neutralizing/blood/immunology[MESH]
  • |Antibodies, Viral/*blood/immunology[MESH]
  • |COVID-19 Vaccines/adverse effects/*immunology[MESH]
  • |COVID-19/prevention & control[MESH]
  • |Immunization, Secondary/*methods[MESH]
  • |Interferon-gamma/blood[MESH]
  • |Lymphocyte Count[MESH]
  • |Mice[MESH]
  • |Mice, Inbred BALB C[MESH]
  • |SARS-CoV-2/immunology[MESH]
  • |T-Lymphocytes, Helper-Inducer/immunology[MESH]
  • |T-Lymphocytes/immunology[MESH]
  • |Vaccination/adverse effects[MESH]
  • |Vaccines, Subunit/administration & dosage/*immunology[MESH]
  • |Vaccines, Synthetic/administration & dosage/*immunology[MESH]


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