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Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 J+Clin+Epidemiol 2021 ; 135 (ä): 125-135 Nephropedia Template TP
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The methodological quality is insufficient in clinical practice guidelines in the context of COVID-19: systematic review #MMPMID33691153
Stamm TA; Andrews MR; Mosor E; Ritschl V; Li LC; Ma JK; Campo-Arias A; Baker S; Burton NW; Eghbali M; Fernandez N; Ferreira RJO; Gabler G; Makri S; Mintz S; Moe RH; Morasso E; Murphy SL; Ntuli S; Omara M; Simancas-Pallares MA; Horonieff J; Gartlehner G
J Clin Epidemiol 2021[Jul]; 135 (ä): 125-135 PMID33691153show ga
OBJECTIVES: The number of published clinical practice guidelines related to COVID-19 has rapidly increased. This study explored if basic methodological standards of guideline development have been met in the published clinical practice guidelines related to COVID-19. STUDY DESIGN AND SETTING: Rapid systematic review from February 1 until April 27, 2020 using MEDLINE [PubMed], CINAHL [Ebsco], Trip and manual search, including all types of healthcare workers providing any kind of healthcare to any patient population in any setting. RESULTS: There were 1342 titles screened and 188 guidelines included. The highest average AGREE II domain score was 89% for scope and purpose, the lowest for rigor of development (25%). Only eight guidelines (4%) were based on a systematic literature search and a structured consensus process by representative experts (classified as the highest methodological quality). The majority (156; 83%) was solely built on an informal expert consensus. A process for regular updates was described in 27 guidelines (14%). Patients were included in the development of only one guideline. CONCLUSION: Despite clear scope, most publications fell short of basic methodological standards of guideline development. Clinicians should use guidelines that include up-to-date information, were informed by stakeholder involvement, and employed rigorous methodologies.