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10.1016/j.stemcr.2020.12.010

http://scihub22266oqcxt.onion/10.1016/j.stemcr.2020.12.010
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suck abstract from ncbi


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pmid33691145      Stem+Cell+Reports 2021 ; 16 (3): 398-411
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  • Broad-Spectrum Anti-coronavirus Vaccines and Therapeutics to Combat the Current COVID-19 Pandemic and Future Coronavirus Disease Outbreaks #MMPMID33691145
  • Cao M; Su X; Jiang S
  • Stem Cell Reports 2021[Mar]; 16 (3): 398-411 PMID33691145show ga
  • While the COVID-19 pandemic caused by SARS-CoV-2 is continuing, it may become worse in the coming winter months with a high potential for the emergence and spread of escape variants of SARS-CoV-2. SARS-related CoVs (SARSr-CoVs) from bats may also cause outbreaks of emerging coronavirus diseases in the future. These predictions call for the development of broad-spectrum anti-coronavirus vaccines and therapeutics to combat the current COVID-19 pandemic and future emerging coronavirus disease epidemics. In this review, we describe advances and challenges in the development of broad-spectrum vaccines and neutralizing antibodies against lineage B betacoronaviruses (beta-CoV-Bs), including SARS-CoV-2, SARS-CoV, and SARSr-CoVs, as well as peptide-based pan-CoV fusion inhibitors and their potential in the prevention and treatment of COVID-19 and other human coronavirus infections.
  • |*COVID-19 Drug Treatment[MESH]
  • |Animals[MESH]
  • |Antiviral Agents/*therapeutic use[MESH]
  • |COVID-19 Vaccines/*immunology[MESH]
  • |COVID-19/*immunology/virology[MESH]
  • |Disease Outbreaks[MESH]
  • |Humans[MESH]
  • |Pandemics/*prevention & control[MESH]


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