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10.1016/j.ygeno.2021.01.026

http://scihub22266oqcxt.onion/10.1016/j.ygeno.2021.01.026
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33691144!7937330!33691144
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suck abstract from ncbi


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pmid33691144      Genomics 2021 ; 113 (3): 1219-1233
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  • Single-cell RNA sequencing reveals the sustained immune cell dysfunction in the pathogenesis of sepsis secondary to bacterial pneumonia #MMPMID33691144
  • Wang T; Zhang X; Liu Z; Yao T; Zheng D; Gan J; Yu S; Li L; Chen P; Sun J
  • Genomics 2021[May]; 113 (3): 1219-1233 PMID33691144show ga
  • Sepsis is a leading cause of mortality in intensive care unit worldwide, it's accompanied by immune cell dysfunction induced by multiple factors. However, little is known about the specific alterations in immune cells in the dynamic pathogenesis of sepsis secondary to bacterial pneumonia. Here, we used single cell RNA sequencing (scRNA-seq) to profile peripheral blood mononuclear cells (PBMCs) in a healthy control and two patients with sepsis secondary to bacterial pneumonia, including acute, stable and recovery stage. We analyzed the quantity and function of immune cells. During disease course, interferon gamma response was upregulated; T/NK cell subtypes presented activation and exhaustion properties, which might be driven by monocytes through IL-1beta signaling pathways; The proportion of plasma cells was increased, which might be driven by NK cells through IFN signaling pathways; Additionally, interferon gamma response was upregulated to a greater degree in sepsis secondary to pneumonia induced by SARS-COV-2 compared with that induced by influenza virus and bacteria.
  • |*Pneumonia, Bacterial/complications/genetics/immunology[MESH]
  • |*Sepsis/genetics/immunology/microbiology/virology[MESH]
  • |Aged[MESH]
  • |COVID-19/complications/genetics/immunology[MESH]
  • |Case-Control Studies[MESH]
  • |Cells, Cultured[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Influenza, Human/complications/genetics/immunology[MESH]
  • |Leukocytes, Mononuclear/immunology/metabolism[MESH]
  • |Leukocytes/immunology/metabolism[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Monocytes/immunology/metabolism[MESH]
  • |RNA-Seq[MESH]
  • |SARS-CoV-2/immunology[MESH]
  • |Sequence Analysis, RNA/*methods[MESH]


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