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10.1016/j.cell.2021.02.026 http://scihub22266oqcxt.onion/10.1016/j.cell.2021.02.026 33691139!7879018!33691139     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell 2021 ; 184 (7): 1804-1820.e16 Nephropedia Template TP {{tp|p=33691139|t=2021. Human neutralizing antibodies against SARS-CoV-2 require intact Fc effector functions for optimal therapeutic protection |pdf=|usr=}}{{33691139}} gab.com Text Human neutralizing antibodies against SARS-CoV-2 require intact Fc effector functions for optimal therapeutic protection JO: Cell http://www.kidney.de/pget.php?&tw=1&pmid=33691139 #FOAvip SARS-CoV-2 has caused the global COVID-19 pandemic. Although passively delivered neutralizing antibodies against SARS-CoV-2 show promise in clinical trials, their mechanism of action in vivo is incompletely understood. Here, we define correlates of protection of neutralizing human monoclonal antibodies (mAbs) in SARS-CoV-2-infected animals. Whereas Fc effector functions are dispensable when representative neutralizing mAbs are administered as prophylaxis, they are required for optimal protection as therapy. When given after infection, intact mAbs reduce SARS-CoV-2 burden and lung disease in mice and hamsters better than loss-of-function Fc variant mAbs. Fc engagement of neutralizing antibodies mitigates inflammation and improves respiratory mechanics, and transcriptional profiling suggests these phenotypes are associated with diminished innate immune signaling and preserved tissue repair. Immune cell depletions establish that neutralizing mAbs require monocytes and CD8(+) T cells for optimal clinical and virological benefit. Thus, potently neutralizing mAbs utilize Fc effector functions during therapy to mitigate lung infection and disease. Twit Text FOAVip Human neutralizing antibodies against SARS-CoV-2 require intact Fc effector functions for optimal therapeutic protection ????Cell http://www.kidney.de/pget.php?&tw=1&pmid=33691139 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33691139 #FOAvip English Wikipedia <ref>{{Cite pmid|33691139}}</ref> Human neutralizing antibodies against SARS-CoV-2 require intact Fc effector functions for optimal therapeutic protection #MMPMID33691139 Winkler ES; Gilchuk P; Yu J; Bailey AL; Chen RE; Chong Z; Zost SJ; Jang H; Huang Y; Allen JD; Case JB; Sutton RE; Carnahan RH; Darling TL; Boon ACM; Mack M; Head RD; Ross TM; Crowe JE Jr; Diamond MS Cell 2021[Apr]; 184 (7): 1804-1820.e16 PMID33691139show ga SARS-CoV-2 has caused the global COVID-19 pandemic. Although passively delivered neutralizing antibodies against SARS-CoV-2 show promise in clinical trials, their mechanism of action in vivo is incompletely understood. Here, we define correlates of protection of neutralizing human monoclonal antibodies (mAbs) in SARS-CoV-2-infected animals. Whereas Fc effector functions are dispensable when representative neutralizing mAbs are administered as prophylaxis, they are required for optimal protection as therapy. When given after infection, intact mAbs reduce SARS-CoV-2 burden and lung disease in mice and hamsters better than loss-of-function Fc variant mAbs. Fc engagement of neutralizing antibodies mitigates inflammation and improves respiratory mechanics, and transcriptional profiling suggests these phenotypes are associated with diminished innate immune signaling and preserved tissue repair. Immune cell depletions establish that neutralizing mAbs require monocytes and CD8(+) T cells for optimal clinical and virological benefit. Thus, potently neutralizing mAbs utilize Fc effector functions during therapy to mitigate lung infection and disease. |*Antibodies, Monoclonal/immunology/therapeutic use[MESH] |*Antibodies, Neutralizing/immunology/therapeutic use[MESH] |*Antibodies, Viral/immunology/therapeutic use[MESH] |*CD8-Positive T-Lymphocytes/cytology/immunology[MESH] |*COVID-19/immunology/therapy[MESH] |Animals[MESH] |CHO Cells[MESH] |Chlorocebus aethiops[MESH] |Cricetulus[MESH] |Disease Models, Animal[MESH] |Female[MESH] |Humans[MESH] |Immunoglobulin Fc Fragments/*immunology[MESH] |Male[MESH] |Mice[MESH] |Mice, Inbred C57BL[MESH] |SARS-CoV-2/immunology[MESH] |Vero Cells[MESH]Human neutralizing antibodies against SARS-CoV-2 require intact Fc eff(epmc).pdf DeepDyve Pubget Overpricing