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10.1371/journal.pcbi.1008688 http://scihub22266oqcxt.onion/10.1371/journal.pcbi.1008688 33690626!7943003!33690626     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       PLoS+Comput+Biol 2021 ; 17 (3): e1008688 Nephropedia Template TP {{tp|p=33690626|t=2021. Assessing the feasibility and effectiveness of household-pooled universal testing to control COVID-19 epidemics |pdf=|usr=}}{{33690626}} gab.com Text Assessing the feasibility and effectiveness of household-pooled universal testing to control COVID-19 epidemics JO: PLoS Comput Biol http://www.kidney.de/pget.php?&tw=1&pmid=33690626 #FOAvip Outbreaks of SARS-CoV-2 are threatening the health care systems of several countries around the world. The initial control of SARS-CoV-2 epidemics relied on non-pharmaceutical interventions, such as social distancing, teleworking, mouth masks and contact tracing. However, as pre-symptomatic transmission remains an important driver of the epidemic, contact tracing efforts struggle to fully control SARS-CoV-2 epidemics. Therefore, in this work, we investigate to what extent the use of universal testing, i.e., an approach in which we screen the entire population, can be utilized to mitigate this epidemic. To this end, we rely on PCR test pooling of individuals that belong to the same households, to allow for a universal testing procedure that is feasible with the limited testing capacity. We evaluate two isolation strategies: on the one hand pool isolation, where we isolate all individuals that belong to a positive PCR test pool, and on the other hand individual isolation, where we determine which of the individuals that belong to the positive PCR pool are positive, through an additional testing step. We evaluate this universal testing approach in the STRIDE individual-based epidemiological model in the context of the Belgian COVID-19 epidemic. As the organisation of universal testing will be challenging, we discuss the different aspects related to sample extraction and PCR testing, to demonstrate the feasibility of universal testing when a decentralized testing approach is used. We show through simulation, that weekly universal testing is able to control the epidemic, even when many of the contact reductions are relieved. Finally, our model shows that the use of universal testing in combination with stringent contact reductions could be considered as a strategy to eradicate the virus. Twit Text FOAVip Assessing the feasibility and effectiveness of household-pooled universal testing to control COVID-19 epidemics ????PLoS Comput Biol http://www.kidney.de/pget.php?&tw=1&pmid=33690626 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33690626 #FOAvip English Wikipedia <ref>{{Cite pmid|33690626}}</ref> Assessing the feasibility and effectiveness of household-pooled universal testing to control COVID-19 epidemics #MMPMID33690626 Libin PJK; Willem L; Verstraeten T; Torneri A; Vanderlocht J; Hens N PLoS Comput Biol 2021[Mar]; 17 (3): e1008688 PMID33690626show ga Outbreaks of SARS-CoV-2 are threatening the health care systems of several countries around the world. The initial control of SARS-CoV-2 epidemics relied on non-pharmaceutical interventions, such as social distancing, teleworking, mouth masks and contact tracing. However, as pre-symptomatic transmission remains an important driver of the epidemic, contact tracing efforts struggle to fully control SARS-CoV-2 epidemics. Therefore, in this work, we investigate to what extent the use of universal testing, i.e., an approach in which we screen the entire population, can be utilized to mitigate this epidemic. To this end, we rely on PCR test pooling of individuals that belong to the same households, to allow for a universal testing procedure that is feasible with the limited testing capacity. We evaluate two isolation strategies: on the one hand pool isolation, where we isolate all individuals that belong to a positive PCR test pool, and on the other hand individual isolation, where we determine which of the individuals that belong to the positive PCR pool are positive, through an additional testing step. We evaluate this universal testing approach in the STRIDE individual-based epidemiological model in the context of the Belgian COVID-19 epidemic. As the organisation of universal testing will be challenging, we discuss the different aspects related to sample extraction and PCR testing, to demonstrate the feasibility of universal testing when a decentralized testing approach is used. We show through simulation, that weekly universal testing is able to control the epidemic, even when many of the contact reductions are relieved. Finally, our model shows that the use of universal testing in combination with stringent contact reductions could be considered as a strategy to eradicate the virus. |*SARS-CoV-2[MESH] |Belgium/epidemiology[MESH] |COVID-19 Nucleic Acid Testing/*methods/statistics & numerical data/trends[MESH] |COVID-19/*epidemiology/*prevention & control/transmission[MESH] |Computational Biology[MESH] |Computer Simulation[MESH] |Contact Tracing/methods/statistics & numerical data/trends[MESH] |Epidemics/*prevention & control[MESH] |False Negative Reactions[MESH] |Family Characteristics[MESH] |Feasibility Studies[MESH] |Humans[MESH] |Mass Screening/methods/statistics & numerical data/trends[MESH] |Models, Statistical[MESH] |Quarantine/methods/statistics & numerical data/trends[MESH]Assessing the feasibility and effectiveness of household-pooled univer(epmc).pdf DeepDyve Pubget Overpricing