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10.1134/S1607672921010130

http://scihub22266oqcxt.onion/10.1134/S1607672921010130
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33689070!7944473!33689070
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suck abstract from ncbi


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pmid33689070      Dokl+Biochem+Biophys 2021 ; 496 (1): 27-31
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  • Novel Negative Sense Genes in the RNA Genome of Coronaviruses #MMPMID33689070
  • Zhirnov OP; Poyarkov SV
  • Dokl Biochem Biophys 2021[May]; 496 (1): 27-31 PMID33689070show ga
  • The coronavirus family consists of lipid-containing envelope viruses that have a single-stranded RNA genome that encodes 25-30 proteins in different viruses by the mechanism of positive-polarity strategy. In addition, extended open reading trnslation frames (ORFs, genes) located in a negative-sense orientation were found in the genomes of coronaviruses. The size of negative-sense genes varies in the range of 150-450 nt, which corresponds to polypeptides encoded by negative-polarity genes (negative gene proteins, NGP) with m. m. 5-30 x 10(3) kDa. Coronaviruses show marked differences from virus to virus in the number of negative genes detected. These negative-sense genes in the coronavirus genome allow this family to be considered as viruses developing an ambisense genome strategy.
  • |*Genomics[MESH]
  • |Base Sequence[MESH]
  • |Genes, Viral/*genetics[MESH]
  • |Open Reading Frames/genetics[MESH]
  • |RNA, Viral/*genetics[MESH]


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