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10.1126/scisignal.abc5763 http://scihub22266oqcxt.onion/10.1126/scisignal.abc5763 33688079!8491136!33688079     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Signal 2021 ; 14 (673): ä Nephropedia Template TP {{tp|p=33688079|t=2021. Identification of human immune cell subtypes most responsive to IL-1beta-induced inflammatory signaling using mass cytometry |pdf=|usr=}}{{33688079}} gab.com Text Identification of human immune cell subtypes most responsive to IL-1beta-induced inflammatory signaling using mass cytometry JO: Sci Signal http://www.kidney.de/pget.php?&tw=1&pmid=33688079 #FOAvip IL-1beta is a key mediator of the cytokine storm linked to high morbidity and mortality from COVID-19, and IL-1beta blockade with anakinra and canakinumab during COVID-19 infection has entered clinical trials. Using mass cytometry of human peripheral blood mononuclear cells, we identified effector memory CD4(+) T cells and CD4(-)CD8(low/-)CD161(+) T cells, specifically those positive for the chemokine receptor CCR6, as the circulating immune subtypes with the greatest response to IL-1beta. This response manifested as increased phosphorylation and, thus, activation of the proinflammatory transcription factor NF-kappaB and was also seen in other subsets, including CD11c(+) myeloid dendritic cells, classical monocytes, two subsets of natural killer cells (CD16(-)CD56(bright)CD161(-) and CD16(-)CD56(dim)CD161(+)), and lineage(-) (Lin(-)) cells expressing CD161 and CD25. IL-1beta also induced a rapid but less robust increase in the phosphorylation of the kinase p38 as compared to that of NF-kappaB in most of these immune cell subsets. Prolonged IL-1beta stimulation increased the phosphorylation of the transcription factor STAT3 and to a lesser extent that of STAT1 and STAT5 across various immune cell types. IL-1beta-induced production of IL-6 likely led to the activation of STAT1 and STAT3 at later time points. Interindividual heterogeneity and inhibition of STAT activation by anakinra raise the possibility that assays measuring NF-kappaB phosphorylation in response to IL-1beta in CCR6(+) T cell subtypes could identify those patients at higher risk of cytokine storm and most likely to benefit from IL-1beta-neutralizing therapies. Twit Text FOAVip Identification of human immune cell subtypes most responsive to IL-1beta-induced inflammatory signaling using mass cytometry ????Sci Signal http://www.kidney.de/pget.php?&tw=1&pmid=33688079 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33688079 #FOAvip English Wikipedia <ref>{{Cite pmid|33688079}}</ref> Identification of human immune cell subtypes most responsive to IL-1beta-induced inflammatory signaling using mass cytometry #MMPMID33688079 Kothari H; Williams CM; McSkimming C; Drago F; Marshall MA; Garmey J; Vigneshwar M; Zunder ER; McNamara CA Sci Signal 2021[Mar]; 14 (673): ä PMID33688079show ga IL-1beta is a key mediator of the cytokine storm linked to high morbidity and mortality from COVID-19, and IL-1beta blockade with anakinra and canakinumab during COVID-19 infection has entered clinical trials. Using mass cytometry of human peripheral blood mononuclear cells, we identified effector memory CD4(+) T cells and CD4(-)CD8(low/-)CD161(+) T cells, specifically those positive for the chemokine receptor CCR6, as the circulating immune subtypes with the greatest response to IL-1beta. This response manifested as increased phosphorylation and, thus, activation of the proinflammatory transcription factor NF-kappaB and was also seen in other subsets, including CD11c(+) myeloid dendritic cells, classical monocytes, two subsets of natural killer cells (CD16(-)CD56(bright)CD161(-) and CD16(-)CD56(dim)CD161(+)), and lineage(-) (Lin(-)) cells expressing CD161 and CD25. IL-1beta also induced a rapid but less robust increase in the phosphorylation of the kinase p38 as compared to that of NF-kappaB in most of these immune cell subsets. Prolonged IL-1beta stimulation increased the phosphorylation of the transcription factor STAT3 and to a lesser extent that of STAT1 and STAT5 across various immune cell types. IL-1beta-induced production of IL-6 likely led to the activation of STAT1 and STAT3 at later time points. Interindividual heterogeneity and inhibition of STAT activation by anakinra raise the possibility that assays measuring NF-kappaB phosphorylation in response to IL-1beta in CCR6(+) T cell subtypes could identify those patients at higher risk of cytokine storm and most likely to benefit from IL-1beta-neutralizing therapies. |COVID-19/blood/complications/*immunology[MESH] |Cytokine Release Syndrome/blood/etiology/immunology[MESH] |Dendritic Cells/immunology/metabolism[MESH] |Flow Cytometry[MESH] |Humans[MESH] |Interleukin-1beta/*blood/pharmacology[MESH] |Killer Cells, Natural/immunology/metabolism[MESH] |Monocytes/classification/immunology/metabolism[MESH] |NF-kappa B/blood[MESH] |Pandemics[MESH] |Phosphorylation[MESH] |Receptors, CCR6/blood[MESH] |SARS-CoV-2[MESH] |STAT Transcription Factors/blood/immunology[MESH] |Signal Transduction/immunology[MESH] |T-Lymphocyte Subsets/*immunology/metabolism[MESH]Identification of human immune cell subtypes most responsive to IL-1be(epmc).pdf DeepDyve Pubget Overpricing